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RABEPK — TLR3
Text-mined interactions from Literome
Shu et al., Clin Exp Immunol 2007
:
natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-12
p40 in
response to
Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Al-Salleeh et al., Microbes Infect 2007
:
Thus
TLR3 and TLR7
contribute to TMEV induced IL-23 p19 and
p40 , while TLR3 contributes to TMEV induced IFN-beta
Brentano et al., Ann Rheum Dis 2009
(Arthritis, Rheumatoid...) :
The
TLR dependent induction of p19 but not
p40 in RASF and the abundant expression of p19 along with the low or undetectable levels of IL23 in patients with RA provides strong evidence that p19 does not necessarily indicate the presence of IL23, as has been proposed to date
Römmler et al., J Immunol 2013
:
Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888,
TLR7 induced TNF-a release and TLR7- and TLR9 induced
IL-12p40 release were significantly more impaired by G-modified INH-ODNs