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Wong et al., J Toxicol Environ Health 2002
:
Nuclear factor kappaB (NF-kappaB) binding was increased
at 2 and 8 h in cells subjected to synchronous and delayed synchronous VT exposure in the
presence of
LPS
Gupta et al., Mol Cell Biochem 2004
(Endotoxemia) :
The data revealed that
LPS induces MEPD-sensitive inflammatory response syndrome ( SIRS )
at 2- and 24 h post endotoxemia
Zhang et al., Inflammation 2008
(Inflammation) :
To investigate the role of glutathione ( GSH ) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine ( GLN ) in
lipopolysaccharide (LPS) stimulated
alveolar type II (AT-II) epithelial cells of rat lungs ... Supplementation of GLN could increase the GSH level and attenuate the release of TNF-alpha in
LPS stimulated
AT-II cells in a dose-dependant manner ... As a precursor of GSH, glutamine could prevent the NF-kappaB activation and attenuate the release of TNF-alpha in
LPS stimulated
AT-II cells and the effect may be mediated via GSH synthesis
Scicluna et al., Eur J Pharmacol 2009
:
At 2h in the
presence of
LPS , there was increased relaxation to ANP in arteries exposed to LPS [ 16.3+/-2.4 %, P < 0.05 ]
Stabile et al., Peptides 2010
(Endotoxemia) :
LPS significantly
increased plasma OT concentration
at 2 and 4h post-injection
Wang et al., Experimental biology and medicine (Maywood, N.J.) 2012
(Inflammation) :
Like Ang II,
LPS increased the expression of AT1R,
AT2R and LOX-1
Futran et al., J Immunol 1989
:
Inhibition of protein synthesis with anisomycin or inhibition of transcription with actinomycin-D blocked the increased expression of TfR at 4 h. Northern blot analysis showed a marked
increase of TfR mRNA
at 2 and 4 h with either anti-mu or
LPS which was then followed by an apparent decline at 16 h
Burnier et al., Br J Pharmacol 1995
:
5. The
effect of
LPS on the
angiotensin II receptor was dose-, time- and protein-synthesis dependent and was associated with an increased expression of the receptor gene
Cheng et al., Naunyn Schmiedebergs Arch Pharmacol 1998
(Endotoxemia) :
LPS reduced MAP, CO, RBF as well as MBF
at 2.5 and 4 h, and increased TPR at 2.5 but not 4 h. Whereas MB alone had no effects on measured variables in control rats at 4 h, in LPS treated rats, it elevated TPR at all doses and attenuated the fall in MAP at the two low doses