Geng et al., Proc Natl Acad Sci U S A 2011
:
Mechanistically, Fstl1 interacted directly with BMP4, negatively regulated BMP4/Smad1/5/8 signaling, and inhibited BMP4 induced surfactant gene expression
Ogura et al., Circulation 2012
(Disease Models, Animal...) :
Ischemia/reperfusion led to enhancement of bone morphogenetic protein-4 expression and Smad1/5/8 phosphorylation in the heart, and FSTL1 suppressed the increased phosphorylation of Smad1/5/8 in ischemic myocardium