◀ Back to TP53
RB1 — TP53
Pathways - manually collected, often from reviews:
-
BioCarta telomeres telomerase cellular aging and immortality:
p53/RB complex (TP53-RB1)
→
RNA POL II (POLR2A)
(modification, inhibits)
-
BioCarta telomeres telomerase cellular aging and immortality:
p53/RB complex (TP53-RB1)
→
TERT
(modification, inhibits)
-
BioCarta tumor suppressor arf inhibits ribosomal biogenesis:
p53 (TP53)
→
RB (RB1)
(transcription, inhibits)
-
FastForward regulation:
TP53
→
RB1
(transcriptional regulation, decrease)
Osifchin et al., J Biol Chem 1994*
Evidence: DNABINDING, PROMACTIVITY
-
FastForward regulation:
TP53
→
RB1
(transcriptional regulation, unknown)
Osifchin et al., J Biol Chem 1994*
Evidence: DNABINDING, PROMACTIVITY
-
FastForward regulation:
TP53
→
RB1
(transcriptional regulation, increase)
Osifchin et al., J Biol Chem 1994*
Evidence: DNABINDING, PROMACTIVITY
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Guenova et al., Mod Pathol 1999
(Hodgkin Disease) :
In 93 % of the cases studied,
pRb was
detected in HRS, whereas all cases showed overexpression of
p53
Turovets et al., Genetika 1999
:
Protein p21WAF is transactivated by p53 and is responsible for the cell block in the G1 phase of the damaged cells ; protein
pRb is a target for p21WAF which controls the G1-S-phase transition ; and p19ARF protein is
responsible for
p53 activation in cells with certain anomalies
Porrello et al., J Cell Biol 2000
:
p53 regulates myogenesis by triggering the differentiation activity of
pRb
Kuhn et al., Biochim Biophys Acta 2002
:
However, as experiments in p53 deficient cell lines indicated, the decrease of
pRb and E2F-1 is
independent of
p53 and p21 expression
Hovig et al., Cancer Genet Cytogenet 1992
(Eye Neoplasms...) :
If both RB1 and
TP53 are
involved in the initiation of
osteosarcoma , the mechanisms for development of the retinoblastoma and osteosarcoma tumors are different
Tong et al., Oncogene 2004
(Carcinoma, Non-Small-Cell Lung...) :
The enhanced levels of p21WAF1 and
p130/RB2 , in the Cyr61 expressing H520-Cyr61 cells, were also
inhibited by blocking
p53 showing that p21 and p130 were induced by p53 in these cells
Balsitis et al., J Virol 2005
(Hyperplasia...) :
These data show that E7 upregulates the expression of
p53 and p21 via
pRb dependent mechanisms distinct from the proposed p19-Mdm2 pathway
Kitagawa et al., Oncogene 2008
(Neoplasms) :
We demonstrate that adenovirus E1A increases Nutlin-3 induced apoptosis through
pRb inhibition in mouse embryonic fibroblast cells in a
p53 dependent manner
Walkley et al., Genes Dev 2008
(Bone Neoplasms...) :
Conditional mouse
osteosarcoma ,
dependent on
p53 loss and potentiated by loss of Rb, mimics the human disease
Kim et al., Spine J 2009
(Intervertebral Disc Displacement) :
Western blotting showed that the expressions of p53, p21, and pRB displayed a corresponding pattern, that is, a strong
p53 expression
led to strong p21 and
pRB expressions and vice versa
Chano et al., PloS one 2010
(Neoplasms) :
The nuclear RB1CC1 complex involving hSNF5 and/or
p53 activated transcription of
RB1 , p16 and p21, and suppressed tumor cell growth
To et al., BMC cancer 2012
(Retinal Neoplasms...) :
During retinal tumorigenesis, miR-24 may intrinsically compromise the
p53 response to
RB1 loss
Laborde et al., Laryngoscope 2012
(Carcinoma, Squamous Cell...) :
HPV oncogenesis involves expression of E6/E7 oncoproteins, with downstream
p53 degradation and
pRb inhibition
Slebos et al., Proc Natl Acad Sci U S A 1994
:
The cyclin associated protein p21waf1/cip1 has recently been shown to be induced by
p53 and to
inhibit cyclin complex mediated phosphorylation of
pRB in vitro ... Thus, we investigated a possible role for
pRB in the
p53 mediated DNA damage response ... Our results suggest that
p53 indirectly
regulates phosphorylation of
pRB and that pRB and/or other pRB-like molecules that bind to HPV16 E7 participate in the DNA damage mediated G1 arrest signal
Chiou et al., J Virol 1997
:
An E1A mutation that specifically disrupted the p300 binding activity failed to induce p53 accumulation, whereas mutations in E1A which affected
pRb binding
induced p53 accumulation