Gene interactions and pathways from curated databases and text-mining

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RB1 — TP53

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Guenova et al., Mod Pathol 1999 (Hodgkin Disease) : In 93 % of the cases studied, pRb was detected in HRS, whereas all cases showed overexpression of p53
Turovets et al., Genetika 1999 : Protein p21WAF is transactivated by p53 and is responsible for the cell block in the G1 phase of the damaged cells ; protein pRb is a target for p21WAF which controls the G1-S-phase transition ; and p19ARF protein is responsible for p53 activation in cells with certain anomalies
Porrello et al., J Cell Biol 2000 : p53 regulates myogenesis by triggering the differentiation activity of pRb
Kuhn et al., Biochim Biophys Acta 2002 : However, as experiments in p53 deficient cell lines indicated, the decrease of pRb and E2F-1 is independent of p53 and p21 expression
Hovig et al., Cancer Genet Cytogenet 1992 (Eye Neoplasms...) : If both RB1 and TP53 are involved in the initiation of osteosarcoma , the mechanisms for development of the retinoblastoma and osteosarcoma tumors are different
Tong et al., Oncogene 2004 (Carcinoma, Non-Small-Cell Lung...) : The enhanced levels of p21WAF1 and p130/RB2 , in the Cyr61 expressing H520-Cyr61 cells, were also inhibited by blocking p53 showing that p21 and p130 were induced by p53 in these cells
Balsitis et al., J Virol 2005 (Hyperplasia...) : These data show that E7 upregulates the expression of p53 and p21 via pRb dependent mechanisms distinct from the proposed p19-Mdm2 pathway
Kitagawa et al., Oncogene 2008 (Neoplasms) : We demonstrate that adenovirus E1A increases Nutlin-3 induced apoptosis through pRb inhibition in mouse embryonic fibroblast cells in a p53 dependent manner
Walkley et al., Genes Dev 2008 (Bone Neoplasms...) : Conditional mouse osteosarcoma , dependent on p53 loss and potentiated by loss of Rb, mimics the human disease
Kim et al., Spine J 2009 (Intervertebral Disc Displacement) : Western blotting showed that the expressions of p53, p21, and pRB displayed a corresponding pattern, that is, a strong p53 expression led to strong p21 and pRB expressions and vice versa
Chano et al., PloS one 2010 (Neoplasms) : The nuclear RB1CC1 complex involving hSNF5 and/or p53 activated transcription of RB1 , p16 and p21, and suppressed tumor cell growth
To et al., BMC cancer 2012 (Retinal Neoplasms...) : During retinal tumorigenesis, miR-24 may intrinsically compromise the p53 response to RB1 loss
Laborde et al., Laryngoscope 2012 (Carcinoma, Squamous Cell...) : HPV oncogenesis involves expression of E6/E7 oncoproteins, with downstream p53 degradation and pRb inhibition
Slebos et al., Proc Natl Acad Sci U S A 1994 : The cyclin associated protein p21waf1/cip1 has recently been shown to be induced by p53 and to inhibit cyclin complex mediated phosphorylation of pRB in vitro ... Thus, we investigated a possible role for pRB in the p53 mediated DNA damage response ... Our results suggest that p53 indirectly regulates phosphorylation of pRB and that pRB and/or other pRB-like molecules that bind to HPV16 E7 participate in the DNA damage mediated G1 arrest signal
Chiou et al., J Virol 1997 : An E1A mutation that specifically disrupted the p300 binding activity failed to induce p53 accumulation, whereas mutations in E1A which affected pRb binding induced p53 accumulation