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ESAT — IFNG

Text-mined interactions from Literome

Mustafa et al., Clin Infect Dis 2000 (Tuberculosis, Pulmonary) : A synthetic-peptide approach was used to map epitope regions of the Mycobacterium tuberculosis 6-kDa early secreted antigen target ( ESAT-6 ) by testing human CD4 ( + ) T cell lines for secretion of IFN-gamma in response to recombinant ESAT-6 ( rESAT-6 ) and overlapping 20-mer peptides covering the antigen sequence
Ulrichs et al., Int J Tuberc Lung Dis 2000 (Tuberculosis) : ESAT-6 is a specific Mycobacterium tuberculosis complex antigen and strong inducer of interferon-gamma (IFN-gamma) production by T cells from tuberculosis patient T-cells
Arend et al., Int J Tuberc Lung Dis 2001 (Tuberculosis, Pulmonary) : IFN-gamma production in response to ESAT-6 and CFP-10 by peripheral blood mononuclear cells from these patients was evaluated before and during anti-tuberculosis treatment ... In all five patients, IFN-gamma responses to ESAT-6 and/or CFP-10 were above the cut-off level defined in a previous study
Menon et al., J Interferon Cytokine Res 2002 : The presence of ESAT-6 as a fusion partner with P71 during immunization, however, resulted in an enhanced P71-specific IFN-gamma response, decreased release of IL-10, and significantly greater ( p < 0.05 ) IgG2a antibody levels in comparison to immunizing with P71 alone
Cardoso et al., Infect Immun 2002 (Tuberculosis, Pleural...) : Nevertheless, the levels of IFN-gamma in response to the antigen ESAT , but not to antigen 85B ( Ag85B ) and purified protein derivative (PPD), were significantly lower in controls than in patients with treated TB or pleural or cavitary TB ... Both CD4 and CD8 T cells were able to release IFN-gamma in response to ESAT
Delgado et al., Int J Tuberc Lung Dis 2004 (Tuberculosis, Pulmonary) : Furthermore, TST skin reaction sizes were significantly larger in Peruvian ( 21.69+/-5.46 mm ) than Cambodian patients ( 11.42+/-7.74 mm ; P < 0.0001 ). IFN-gamma production in response to ESAT-6 correlated with a TST reaction size > 15 mm indicating previous infection with M. tuberculosis ( kappa coefficient of agreement 0.66 ; 95 % CI 0.29-1 )
Olsen et al., Infect Immun 2005 : The production of IFN-gamma by NK cells in whole blood in response to ESAT-6 and MPP14 was demonstrated using intracellular staining together with surface labeling for the NK cell-specific receptor, NKp46, or CD3
Buddle et al., Vet Immunol Immunopathol 2005 (Tuberculosis, Bovine) : IFN-gamma responses to ESAT-6 , antibody responses following tuberculin skin testing and antigen-specific IL-4 mRNA expression all correlated with the severity of disease and indirectly provided an indication of protection
Ferrand et al., Int J Tuberc Lung Dis 2005 (Tuberculosis) : Interferon-gamma responses to ESAT-6 in tuberculosis patients early into and after anti-tuberculosis treatment
Goletti et al., Clin Microbiol Infect 2006 (Tuberculosis) : A previous case-control study reported that an in-vitro interferon (IFN)-gamma response to early secreted antigenic target (ESAT)-6 selected peptides was associated with active tuberculosis ( A-TB )
Pai et al., Journal of occupational medicine and toxicology (London, England) 2006 : IFN-gamma responses to ESAT-6 , CFP-10 and TB7.7 peptides were measured using ELISA, and IFN-gamma > /=0.35 IU/mL was used to define a positive QFT-G test result
Al-Attiyah et al., FEMS Immunol Med Microbiol 2006 (Tuberculosis, Pulmonary) : In the presence of single antigens, IFN-gamma was secreted in response to Ag85B, ESAT6 and MPT64 in TB patients and ESAT6 in healthy donors ... The secretion of IFN-gamma , but not IL-10, in the presence of Ag85B, ESAT6 and MPT64 supports their potential as subunit vaccine candidates against TB
Fox et al., Trans R Soc Trop Med Hyg 2007 (Tuberculosis, Pulmonary) : Commercial tests measuring IFN-gamma responses to ESAT-6 and CFP-10 are available for diagnosing Mycobacterium tuberculosis infection
Ruhwald et al., Microbes Infect 2007 (Tuberculosis) : CXCL10, IL-2, and IFN-gamma responses to stimulation with ESAT-6/CFP10/TB7.7 were assessed in 12 Quantiferon positive, 8 Quantiferon negative tuberculosis patients and 11 Quantiferon negative controls
Li et al., Blood 2008 (Tuberculosis) : CD4+ CD25+ Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6 ... In the present study, we show that ESAT-6 , an antigen of Mycobacterium tuberculosis, induces IFN-gamma secretion by human gammadelta T cells ... Further studies indicated that stimulation with ESAT-6 directly induced purified gammadelta T cells to produce IFN-gamma , independent of both antigen presenting cells and CD4 ( + ) T cells
Wang et al., J Immunol 2009 : ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells ... Recombinant ESAT-6 , but not CFP10, markedly inhibited IFN-gamma production by T cells stimulated with M. tuberculosis or with the combination of anti-CD3 and anti-CD28, in a dose dependent manner
Hasan et al., PloS one 2009 : ESAT6 induced IFNgamma and CXCL9 can differentiate severity of tuberculosis ... A positive correlation between ESAT6 induced IFNgamma and CXCL9 was present in all TB patients, but IFNgamma and CCL2 was only correlated in LNTB ... ESAT6 induced IFNgamma and CXCL9 can differentiate between limited and severe TB infections
Hasan et al., Clinical and vaccine immunology : CVI 2009 (Tuberculosis) : The ESAT6 induced IFN-gamma responses were increased in the patients with TB ( P = 0.013 ) compared with those in the EC group ... However, only TST ( + ) ECs showed reduced IFN-gamma responses to ESAT6 ( P = 0.008 ) compared with the responses of the patients with TB
Ogata et al., Mod Rheumatol 2010 (Tuberculosis) : In whole blood from TB patients, ESAT-6 stimulated significant production of IFN-gamma ( 1.30 +/- 1.95 IU/ml ), and TCZ did not inhibit IFN-gamma production ( 1.56 +/- 1.88 IU/ml )
Samten et al., Tuberculosis (Edinb) 2009 : To address this question, we studied the effect of recombinant ESAT-6 and CFP10 on human primary T-cell IFN-gamma secretion and proliferation ... ESAT-6 , but not CFP10, inhibited IFN-gamma production by T cells stimulated with M. tuberculosis or with anti-CD3 plus anti-CD28, in a dose dependent manner
Cho et al., J Infect 2010 (Tuberculosis, Osteoarticular) : In addition to conventional tests for TB, we used ELISPOT assays to measure the IFN-gamma response to ESAT-6 and CFP-10 in T-cells in samples of peripheral blood mononuclear cells ( PBMC )
Buddle et al., Clin Diagn Lab Immunol 1999 (Tuberculosis, Bovine) : Cattle from both the BCG vaccinated and nonvaccinated groups which were M. bovis culture positive following challenge produced IFN-gamma responses to PPDB and ESAT-6 which were significantly stronger than those observed in the corresponding M. bovis culture negative animals