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IL11 — WNT2
Text-mined interactions from Literome
Matsumoto et al., Endocr J 2012
(Wnt Signaling Pathway) :
The increased
IL-11 then suppresses expression of Wnt inhibitors, including Dickkopf 1 (Dkk1) and 2, and
enhances Wnt signaling to stimulate osteoblast differentiation and inhibit adipocyte differentiation ... Thus, factors that enhance osteoblast differentiation stimulate, and those which suppress osteoblast differentiation inhibit IL-11 gene transcription, and
IL-11 enhances
Wnt signaling by suppressing expression of its inhibitors
Kuriwaka-Kido et al., Endocrinology 2013
:
Because
IL-11 suppresses the expression of dickkopf-1 and -2 and
stimulates Wnt signaling, IL-11 appears to mediate at least a part of the effect of mechanical strain on osteoblast differentiation and bone formation