Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202122753-202152434)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ DIABLO ▸ MAPK3 ▸ IL1A ▸
BCL5 ▸ BCL9 ▸ BCL6 ▸ BCL3 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK6 ▸ MAPK11 ▸ MAPK10 ▸ MAPK8 ▸ MAPK14 ▸ MAPK15 ▸ MAPK13 ▸
MAPK9 ▸ MAPK4 ▸ MAPK12 ▸ MAPK7 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN11 ▸ CAPN2 ▸ FADD ▸ CAPN14 ▸ CAPN5 ▸
CAPN12 ▸ CAPN6 ▸ CAPN15 ▸ CAPN9 ▸ CAPN8 ▸ CAPN3 ▸ IL18 ▸
CAPN7 ▸ CAPN13 ▸ ASIP ▸ STS ▸ DNTT ▸ MCL1 ▸ MMP9 ▸
MMP2 ▸ MMP14 ▸ MMP12 ▸ MMP11 ▸ MMP3 ▸ MMP25 ▸ MMP13 ▸
MMP1 ▸ MMP7 ▸ MMP15 ▸ MMP21 ▸ MMP8 ▸ MMP10 ▸ NLRP3 ▸
MMP20 ▸ MMP16 ▸ CDKN1A ▸ MMP28 ▸ MMP27 ▸ MMP24 ▸ MMP19 ▸
MMP17 ▸ MMP26 ▸ JUN ▸ CASP9 ▸ PDCD5 ▸ PDCD11 ▸ RNF19A ▸
CFLAR ▸ CASP12 ▸ PDCD1 ▸ PDCD2 ▸ PDCD10 ▸ PDCD7 ▸ PDCD4 ▸
PDCD6 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ CASP2 ▸ ANXA5 ▸
INS ▸ PCBD1 ▸ AHSA1 ▸ MPZ ▸ HLA-DRB1 ▸ CASP6 ▸ TGFB1 ▸
PI3 ▸ NLRC4 ▸ CASP7 ▸ PIK3CA ▸ CASP5 ▸ CASP14 ▸ PIK3R1 ▸
CASP16 ▸ CASP4 ▸ CASP10 ▸ EPO ▸ DDIT3 ▸ PRKCD ▸ TNFRSF1A ▸
TAT ▸ PRDX2 ▸ DFFA ▸ DISC1 ▸ DISC2 ▸ NOS2 ▸ CRK ▸
PCNA ▸ MYLIP ▸ IL6 ▸ GSK3B ▸ GRAP2 ▸ BIRC2 ▸ IL4 ▸
CTSB ▸ EGF ▸ EIF2AK2 ▸ VEGFA ▸ CAST ▸ IL8 ▸ CTNNB1 ▸
SOD1 ▸ NOS1 ▸ IRF1 ▸ LEP ▸ PTGS2 ▸ PAK2 ▸ DFFB ▸
BID ▸ NGF ▸ ROCK1 ▸ P2RX7 ▸ DNASE1 ▸ ABL1 ▸ APP ▸
DNASE2 ▸ HGF ▸ ALPI ▸ FOS ▸ MAP3K1 ▸ RIPK1 ▸ BCR ▸
IL16 ▸ BDNF ▸ TCF4 ▸ SOD2 ▸ CAT ▸ APEH ▸ CDK2 ▸
MYC ▸ IFI27 ▸ IFNB1 ▸ IL10 ▸ TCF21 ▸ TCF7 ▸ TCF23 ▸
TLR2 ▸ CA2 ▸ HTRA2 ▸ MAP2K1 ▸ NOD2 ▸ IL2 ▸ CSF2 ▸
TCF12 ▸ RAC1 ▸ BMP1 ▸ TCF20 ▸ NFKBIA ▸ NOS3 ▸ TCF19 ▸
TCF3 ▸ TCF15 ▸ NOX1 ▸ TCF25 ▸ HDAC2 ▸ TCF24 ▸ CTSD ▸
UPK3B ▸ MAGT1 ▸ BMP4 ▸ GAL ▸ BAD ▸ ATP5O ▸ ARSK ▸
CDC73 ▸ LMNB1 ▸ TLR4 ▸ CD8A ▸ NOX4 ▸ APOB ▸ FGF2 ▸
ADCYAP1 ▸ STAT1 ▸ SOD3 ▸ BIRC7 ▸ PRKDC ▸ AIM2 ▸ HSPA5 ▸
POLDIP2 ▸ BIRC3 ▸ CSF3 ▸ HDAC1 ▸ TLR3 ▸ NLRP1 ▸ ITIH4 ▸
HMGB1 ▸ BMP5 ▸ STAT3 ▸ RIPK2 ▸ AGTR1 ▸ IL33 ▸ PML ▸
MST1 ▸ BMP6 ▸ PPP2R1A ▸ ENDOG ▸ BMP15 ▸ GZMB ▸ NOX5 ▸
NOX3 ▸ CD79A ▸ CDK5 ▸ BMP2 ▸ TRAF6 ▸ PPP2CA ▸ TLR7 ▸
IL11 ▸ HSPB1 ▸ NOD1 ▸ BMP10 ▸ WDR61 ▸ IL15 ▸ PAF1 ▸
HPR ▸ SMPD2 ▸ PPP2R2B ▸ PDLIM7 ▸ BMP3 ▸ KRT18 ▸ LEO1 ▸
SNAP25 ▸ RB1 ▸ CTR9 ▸ BMP7 ▸ CARD8 ▸ TLR5 ▸ IL3 ▸
IL5 ▸ IL24 ▸ ICAM1 ▸ CDH1 ▸ IL20 ▸ TNFRSF1B ▸ GP2 ▸
RIPK3 ▸ GSN ▸ PGP ▸ CDC6 ▸ RAD51 ▸ TXN ▸ IL21 ▸
HIF1A ▸ PTX4 ▸ GP9 ▸ GP5 ▸ GP6 ▸ ANXA1 ▸ RBBP7 ▸
CREB3 ▸ TLR8 ▸ TLR10 ▸ WAS ▸ CREB5 ▸ PTX3 ▸ PLCG1 ▸
CXCL9 ▸ CSE ▸ BIRC6 ▸ PPARA ▸ RBBP4 ▸ CREB1 ▸ CCDC88A ▸
CD4 ▸ BOC ▸ PRNP ▸ IGF2 ▸ TLR1 ▸ HTT ▸ EGFR ▸
JAK2 ▸ LMNB2 ▸ LPA ▸ APC ▸ MET ▸ MAP2K2 ▸ NPS ▸
EIF2S1 ▸ SYK ▸ SMARCD1 ▸ RENBP ▸ CARD9 ▸ IKBKB ▸ MUC20 ▸
MUC21 ▸ ACHE ▸ IL26 ▸ PLD1 ▸ IL13 ▸ MSC ▸ TLR9 ▸
MUC16 ▸ TRAF1 ▸ KDR ▸ RRAS ▸ CCL2 ▸ RAF1 ▸ HMOX1 ▸
IL19 ▸ IL27 ▸ ANGPT2 ▸ SMARCC1 ▸ SMPD1 ▸ CDK8 ▸ TLR6 ▸
TOP1 ▸ MUC15 ▸ SYT1 ▸ CARD6 ▸ IL22 ▸ MUC8 ▸ MEFV ▸
MUC6 ▸ SMARCD2 ▸ LYN ▸ IL7 ▸ MUC7 ▸ SMARCA4 ▸ MDM2 ▸
IL34 ▸ IL25 ▸ IRF3 ▸ MUC13 ▸ MUC12 ▸ ARID1A ▸ ROCK2 ▸
IL31 ▸ ABCC6 ▸ MUC1 ▸ PAK1 ▸ MUC4 ▸ BRCA1 ▸ CCND1 ▸
STX1A ▸ UCN ▸ GATA1 ▸ FOXO3 ▸ CARD11 ▸ MUC17 ▸ MUC2 ▸
IL37 ▸ PPARG ▸ IL32 ▸ CDA ▸ MUC22 ▸ SMARCA2 ▸ MUC19 ▸
CD79B ▸ IL9 ▸ SMARCC2 ▸ HSPD1 ▸ BECN1 ▸ ACTL6A ▸ SMARCE1 ▸
SMARCB1 ▸ ALB ▸ TNFRSF10A ▸ DST ▸ CEP290 ▸ PIDD ▸ SLC9A1 ▸
PEA15 ▸ CEP164 ▸ IKBKG ▸ PRKCA ▸ CEP85 ▸ CEP250 ▸ PTBP1 ▸
CEP78 ▸ CCR7 ▸ CALM3 ▸ ANGPT1 ▸ PRKCG ▸ HIP1 ▸ VIMP ▸
PLOD2 ▸ ARC ▸ CEP135 ▸ GRK1 ▸ CARD14 ▸ CEP68 ▸ GUCY2D ▸
NPY6R ▸ GRK7 ▸ PRKAR2B ▸ CDK4 ▸ IGF1R ▸ VDAC1 ▸ CARD17 ▸
IRF5 ▸ SKP1 ▸ CEP89 ▸ TARDBP ▸ WNT1 ▸ CEP120 ▸ LYPLA1 ▸
SETBP1 ▸ RASA1 ▸ CEP19 ▸ ARSA ▸ PTEN ▸ GRK6 ▸ DERL1 ▸
CEP95 ▸ TCHP ▸ GRB2 ▸ MAP2K6 ▸ MAP2K5 ▸ CEP192 ▸ IRF4 ▸
NUP210 ▸ IL1RN ▸ HSF1 ▸ PTHLH ▸ TRAF2 ▸ CEP104 ▸ EPX ▸
GDNF ▸ HIST2H2BE ▸ ALK ▸ CEP112 ▸ MAP2K4 ▸ NUP153 ▸ PSEN1 ▸
NUP62 ▸ SLCO6A1 ▸ ELAVL1 ▸ CEP70 ▸ CEP55 ▸ SEC14L2 ▸ CEP76 ▸
MIF ▸ ME2 ▸ BIRC8 ▸ GRB10 ▸ GRB7 ▸ GRB14 ▸ ADIPOQ ▸
BACE1 ▸ TRAF3 ▸ PLD2 ▸ CEP97 ▸ HSP90AA1 ▸ CEP63 ▸ NPM1 ▸
PSMD10 ▸ MAP2K7 ▸ PRKACG ▸ GRK4 ▸ CEP57 ▸ CEP152 ▸ CEP350 ▸
ATG5 ▸ MPST ▸ NUP214 ▸ LAT ▸ MEPE ▸ PXN ▸ PRKACB ▸
VIM ▸ FOXO1 ▸ EHMT1 ▸ IRF2 ▸ PANX1 ▸ CARD10 ▸ PRKAR1A ▸
CD47 ▸ CARD18 ▸ SLC17A5 ▸ MAP2K3 ▸ CEP72 ▸ CEP128 ▸ DES ▸
CEP41 ▸ HUNK ▸ CD40 ▸ BIRC5 ▸ CUL1 ▸ E2F1 ▸ GRK5 ▸
CEP44 ▸ CEP170 ▸ SETD2 ▸ SP1 ▸ SOAT1 ▸ VCP ▸ PRKAR1B ▸
PRKAR2A ▸ PTK2 ▸ H2AFX ▸ CARD16 ▸ BCL2L12 ▸ KLK3 ▸ TRA ▸
CCNC ▸ IFI44 ▸ GPI ▸ VDAC2 ▸ E2F2 ▸ CAPNS1 ▸ EDNRA ▸
MAP3K7 ▸ CISH ▸ PRKAB1 ▸ MED15 ▸ NLRC5 ▸ KLKB1 ▸ TET2 ▸
CSF1 ▸ TRAF5 ▸ SREBF1 ▸ MST1R ▸ CCR3 ▸ PLD6 ▸ HCLS1 ▸
HMGCR ▸ XRCC6 ▸ RBL2 ▸ IRF9 ▸ RAD50 ▸ TET1 ▸ DIDO1 ▸
ACIN1 ▸ TSC22D3 ▸ CIB1 ▸ MLYCD ▸ CCR1 ▸ CDK1 ▸ CXCL13 ▸
ITCH ▸ CD8B ▸ ETS1 ▸ CCR10 ▸ PGF ▸ PRKAG2 ▸ ODC1 ▸
CDK9 ▸ GNRH1 ▸ IRS1 ▸ DAXX ▸ CCNH ▸ CDK7 ▸ APOBEC3D ▸
CDK18 ▸ NAB2 ▸ CYR61 ▸ PPT1 ▸ SMAD7 ▸ CDK20 ▸ SMAD3 ▸
E2F3 ▸ PAEP ▸ CCR5 ▸ CCR6 ▸ PPP1R3A ▸ IDO1 ▸ RAC2 ▸
PIN1 ▸ GJA1 ▸ PRKAB2 ▸ HIPK2 ▸ CCR2 ▸ TGFB3 ▸ XAF1 ▸
FHIT ▸ BAG3 ▸ ADM ▸ TGM2 ▸ CDK3 ▸ PRG4 ▸ RAD21 ▸
ANG ▸ STC1 ▸ ACSM3 ▸ CDK10 ▸ C22orf29 ▸ MED8 ▸ KLF4 ▸
AIP ▸ ETS2 ▸ RAD52 ▸ TFAP2A ▸ NUAK1 ▸ APEX1 ▸ MTA2 ▸
PMEL ▸ AFP ▸ RAB5A ▸ CRYAB ▸ RAC3 ▸ NTF3 ▸ ATG3 ▸
EIF4G3 ▸ MED4 ▸ LRP1 ▸ CTNNBL1 ▸ MED21 ▸ CDK15 ▸ HTRA3 ▸
SAA1 ▸ KMT2A ▸ MT3 ▸ GYS2 ▸ RIPK4 ▸ QRICH2 ▸ IAPP ▸
CALB1 ▸ SDS ▸ WNK1 ▸ RARA ▸ EML2 ▸ PTPN11 ▸ IFIH1 ▸
PAN2 ▸ PRKAA1 ▸ CFL1 ▸ DYRK1A ▸ APIP ▸ EMP3 ▸ MT4 ▸
SATB1 ▸ IGFBP3 ▸ CALML3 ▸ NANOG ▸ FUT1 ▸ GYS1 ▸ MED1 ▸
STX2 ▸ CD2 ▸ NAIP ▸ FOXP3 ▸ SERPINB9 ▸ CCR8 ▸ IARS ▸
CPOX ▸ PNPLA2 ▸ PTCH1 ▸ QRICH1 ▸ GSTT1 ▸ CPA1 ▸ MED24 ▸
GPX3 ▸ TRAF7 ▸ MED7 ▸ IFNA2 ▸ PSMB9 ▸ APOE ▸ CA8 ▸
WNT3A ▸ TMED7 ▸ GRP ▸ HRK ▸ SUB1 ▸ THBS1 ▸ CDK12 ▸
HDAC6 ▸ ADH5 ▸ CCK ▸ SEPT4 ▸ PRKAA2 ▸ MICE ▸ EMP1 ▸
LRRC59 ▸ ID3 ▸ CDK6 ▸ MED14 ▸ ANP32A ▸ CTNND1 ▸ SIVA1 ▸
COP ▸ ACAD8 ▸ NLRP5 ▸ NUP43 ▸ RAD1 ▸ RHO ▸ NPPA ▸
CDK17 ▸ NR0B1 ▸ MED6 ▸ EIF4G2 ▸ RAD18 ▸ DNAJC5 ▸ SERPINA1 ▸
ATM ▸ MED12 ▸ CDK19 ▸ PDGFB ▸ SERP2 ▸ NTN1 ▸ CCR4 ▸
EEF1A2 ▸ BNIP3 ▸ IRF7 ▸ CDK13 ▸ TET3 ▸ PRKAG1 ▸ MME ▸
HDAC4 ▸ CENPK ▸ RUNX3 ▸ SMAD4 ▸ CALR ▸ RANBP2 ▸ GNA11 ▸
ING1 ▸ PLK1 ▸ DHCR24 ▸ S100A12 ▸ CCL19 ▸ BLM ▸ GHSR ▸
HTRA1 ▸ EMP2 ▸ HRD ▸ TAC1 ▸ JAK3 ▸ NTF4 ▸ MTA1 ▸
TAC4 ▸ SRC ▸ EIF4G1 ▸ NACA ▸ NLRP7 ▸ CDK14 ▸ MED17 ▸
ATF5 ▸ PRG2 ▸ JAK1 ▸ TNFRSF8 ▸ MED26 ▸ CTRL ▸ SLPI ▸
DAPK2 ▸ UCP2 ▸ HTRA4 ▸ MAP2 ▸ IRF8 ▸ VIP ▸ NAB1 ▸
PAN3 ▸ PLD4 ▸ ANXA6 ▸ MED25 ▸ ATF2 ▸ CDK16 ▸ CTSL ▸
ERVK-6 ▸ CDC42 ▸ PC ▸ CHUK ▸ TNFSF12 ▸ VDAC3 ▸ PLD3 ▸
ZGLP1 ▸ GLI1 ▸ PSENEN ▸ SHC1 ▸ SERPINF1 ▸ TNFRSF10B ▸ PRG3 ▸
CCR9 ▸ RAD17 ▸ TAC3 ▸ SREBF2 ▸ TRAF4 ▸ DLG1 ▸ FAM168B ▸
ABCD1 ▸ FAF1 ▸ MTA3 ▸ NANOS2 ▸ PARG ▸ MED13 ▸ DAP3 ▸
MED23 ▸ BCAP31 ▸ PLD5 ▸ MTOR ▸ TYR ▸ CXCL17 ▸ GPX1 ▸
LGALS1 ▸ CFTR ▸ STSP1 ▸ SPP1 ▸ TIMP3 ▸ CDCA5 ▸ EP300 ▸
COL4A6 ▸ MAP3K14 ▸ PTPN6 ▸ NOL3 ▸ FIS1 ▸ SORBS1 ▸ HIST1H4A ▸
PCYT1A ▸ USP2 ▸ KARS ▸ COL1A2 ▸ DEDD2 ▸ SPARC ▸ TNFRSF25 ▸
NUCB2 ▸ ITGAV ▸ AR ▸ COL6A1 ▸ EIF3S10 ▸ COL4A3 ▸ CHD3 ▸
YES1 ▸ IQGAP1 ▸ MAPT ▸ CD14 ▸ UBB ▸ TUBA1C ▸ COL11A1 ▸
PIAS1 ▸ RALBP1 ▸ ITGB1 ▸ RALGDS ▸ CD3G ▸ STK24 ▸ NR1H4 ▸
TOPORS ▸ CDK11A ▸ CUL3 ▸ CD3E ▸ OTUD7B ▸ EDA2R ▸ COL5A1 ▸
MALT1 ▸ DNAJC7 ▸ EZR ▸ SYF2 ▸ IRS4 ▸ RPS27L ▸ CD3D ▸
COL11A2 ▸ EIF4A1 ▸ CRADD ▸ DDX28 ▸ NEFH ▸ PARK2 ▸ NCL ▸
COL2A1 ▸ COL4A5 ▸ COL6A2 ▸ TRIM28 ▸ MAP1LC3A ▸ ITGB3 ▸ COL4A4 ▸
MAP1LC3B ▸ PICALM ▸ TUBA1A ▸ PDIA6 ▸ CDK11B ▸ ATAD3A ▸ COL1A1 ▸
LY96 ▸ GRIA1 ▸ RNF135 ▸ COL3A1 ▸ USP54 ▸ PLEC ▸ IL1R2 ▸
PYCARD ▸ TNFAIP3 ▸ UBC ▸ PIDD1 ▸ CLIP3 ▸ TFCP2 ▸ RAB10 ▸
SQSTM1 ▸ IL1R1 ▸ CD247 ▸ MYO9A ▸ COL4A1 ▸ RPS27 ▸ MAP4K4 ▸
PTPN13 ▸ TRIM25 ▸ KHDRBS1 ▸ ARHGDIA ▸ BFAR ▸ ACTA2 ▸ CASP8AP2 ▸
COL7A1 ▸ IFT57 ▸ PLA2G4B ▸ ATG4D ▸ NUCB1 ▸ PRKCI ▸ KRR1 ▸
UBR5 ▸ UBE2D1 ▸ ACTG2 ▸ TUBB ▸ RNF34 ▸ COL5A2 ▸ COL6A3 ▸
HNRNPH2 ▸ UBE2L3 ▸ CLTC ▸ COPS6 ▸ PLIN4 ▸ ATN1 ▸ TICAM2 ▸
ITGA2 ▸ MSN ▸ PARK7 ▸ BNIP3L ▸ TNFSF14 ▸
Data information
Please see the Gene Interactions Track Manual.