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FGF2 — MMP3

Text-mined interactions from Literome

Shimazu et al., J Periodontal Res 2003 : Basic fibroblast growth factor induces the expression of matrix metalloproteinase-3 in human periodontal ligament cells through the MEK2 mitogen activated protein kinase pathway ... However, the role of bFGF on the matrix metalloproteinase-3 (MMP-3) expression in PDL cells is unknown ... In this study, the effect of bFGF on MMP-3 expression in PDL cells and the mechanism of this process were examined ... Furthermore, bFGF increased MMP-3 mRNA levels concentration-dependently as examined by reverse transcription-polymerase chain reaction ( RT-PCR ) ... Thereafter, the MMP-3 mRNA level gradually decreased until 72 h. Cycloheximide blocked the induction of MMP-3 by bFGF , indicating the requirement of de novo protein synthesis for this stimulation ... Furthermore, MMP-3 expression induced by bFGF was abrogated by U0126, a specific inhibitor of MEK1/2 and ERK1/2 in mitogen activated protein ( MAP ) kinase pathway, not by PD98059, a specific inhibitor of MEK1 ... Furthermore, MMP-3 expression induced by bFGF was abrogated by U0126, a specific inhibitor of MEK1/2 and ERK1/2 in mitogen activated protein ( MAP ) kinase pathway, not by PD98059, a specific inhibitor of MEK1 ... These findings suggest that bFGF induces MMP-3 expression in PDL cells through the activation of the MEK2 in MAP kinase pathway
Pintucci et al., J Cell Biochem 2003 : Thus, FGF-2 induces EC expression of MMP-3 with a threshold dose effect that requires sustained activation of the ERK-1/2 pathway
Uchii et al., Arthritis Res Ther 2008 (Disease Models, Animal...) : In cultured chondrocytes, FGF8 induced the release of matrix metalloproteinase 3 and prostaglandin E2, and caused degradation of the ECM
Hughes-Fulford et al., Journal of orthopaedic surgery and research 2011 : We found that FGF-2 caused the most significant induction of expression of early growth response-1 (egr-1), fgf-2, cyclo-oxygenase-2 (cox-2), tgfß and matrix metalloproteinase-3 (mmp-3) associated with proliferation and expression of angiogenic genes like vascular endothelial growth factor A ( vegfA ) and its receptor vegfr1
Giunciuglio et al., Int J Oncol 1995 : Also bFGF alone, a heparin dependent factor, alone can induce endothelial and smooth muscle cell invasion, MMP-2 production and PA activity
Sasaki et al., J Biochem 1998 : An MMP inhibitor partially suppressed the release of bFGF , indicating that matrix degradation is at least partially involved in the IL-1 stimulated bFGF release even if increased production of bFGF is related to the release
Andersen et al., Anticancer Res 1998 (Bone Neoplasms...) : The CAPL protein expressed in cell-cultures appear to block the MMP induction by bFGF and Il-1 alpha