Leng et al., Carcinogenesis 2001
(Colonic Neoplasms) :
In contrast, IGF-II promotes histone deacetylase dependent IGFBP-3 expression and histone deacetylase independent migration
Choi et al., Biochem Biophys Res Commun 2002
(Carcinoma, Hepatocellular) :
Taken together, these results show that Sp1 phosphorylation and the modulation of the Sp1/Sp3/HDAC1 multiprotein complex play a pivotal role in the transcriptional activation of the IGFBP-3 promoter through the Sp1/GC-rich site by TSA