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LPA — MMP2

Text-mined interactions from Literome

Fishman et al., Cancer Res 2001 (Neoplasm Invasiveness...) : In the current study, the effect of LPA on MMP expression and invasive activity was investigated
Matsumoto et al., Jpn J Cancer Res 2001 (Bone Neoplasms...) : High LPA suppressed the activation of MMP2 through down-regulation of MT1-MMP and TIMP2
Wu et al., Endocrinology 2005 : In our present study, we examined the effects of LPA and S1P on MMP-2 expression in human endothelial cells ... We showed that LPA and S1P enhanced MMP-2 expression in mRNA, protein levels, and also enzymatic activity of cells of the EAhy926 human endothelial cell line
Zhao et al., J Biol Chem 2006 : Overexpression of dominant negative PKCdelta or pretreatment with a PKCdelta inhibitor ( rottlerin ) or Src kinase family inhibitor ( PP2 ) partially blocked LPA induced MMP activation, proHB-EGF shedding, and EGFR tyrosine phosphorylation ... Down-regulation of Lyn kinase, but not Src kinase, by specific small interfering RNA mitigated LPA induced MMP activation, proHB-EGF shedding, and EGFR phosphorylation
Do et al., Mol Cancer Res 2007 (Ovarian Neoplasms) : Because the underlying mechanism governing LPA regulation of matrix metalloproteinase-2 (MMP-2) activation remains undefined, we investigated the relationship between LPA induced changes in actin microfilament organization and MMP-2 enzymatic activity ... Inhibition of Rho-kinase/ROCK enhanced both LPA stimulated loss of stress fibers and pro-MMP-2 activation ... In contrast, expression of the constitutively active RhoA ( G14V ) mutant diminished LPA induced pro-MMP-2 activation ... LPA had no effects on membrane type 1-MMP or tissue inhibitor of metalloproteinase-2 expression, but up-regulated MMP-2 levels, contributing to the induction of MMP-2 activation
Wang et al., Gynecol Oncol 2011 (Neoplasm Invasiveness...) : Furthermore, MMP-1 and PAR1 were both significantly induced by LPA ( 20 µM ), and siRNA silencing of MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 )
Dutta et al., Gynecol Oncol 2011 (Neoplasm Invasiveness...) : Additionally, NF-?B inhibition also decreased LPA induced MMP-2 secretion and MMP-1 expression ( p < 0.05 )
Komachi et al., Cancer Sci 2012 (Ascites...) : Ki16198 inhibited LPA induced migration and invasion in several pancreatic cancer cells in vitro, which was associated with the inhibition of LPA induced MMP production
Lou et al., J Int Med Res 2013 (Carcinoma, Hepatocellular...) : This study investigated the effects of LPA on HCC cell invasion and induction of matrix metalloproteinase (MMP) -2 and -9 ... Real-time RT-qPCR showed that LPA increased MMP9, but not MMP2 , expression in HCC cells