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MIF — MMP2

Text-mined interactions from Literome

Meyer-Siegler et al., Cytokine 2000 : Macrophage migration inhibitory factor increases MMP-2 activity in DU-145 prostate cells
Burger-Kentischer et al., Atherosclerosis 2006 (Aortitis...) : Importantly, the local aortic expression of ICAM-1, MMP-2 , TNF, IL-12, and CD40L was reduced by MIF blockade, as were the levels of the phospho-c-Jun and C/EBPbeta transcription factors
Pakozdi et al., Arthritis Res Ther 2006 (Arthritis, Experimental...) : In the present study, we determined the role of MIF in RA synovial fibroblast MMP production and the underlying signaling mechanisms ... We found that MIF induces RA synovial fibroblast MMP-2 expression in a time dependent and concentration dependent manner ... To elucidate the role of MIF in MMP-2 production, we produced zymosan induced arthritis ( ZIA ) in MIF gene-deficient and wild-type mice ... To elucidate the signaling mechanisms in MIF induced MMP-2 upregulation, RA synovial fibroblasts were stimulated with MIF in the presence of signaling inhibitors ... We found that MIF induced RA synovial fibroblast MMP-2 upregulation required the protein kinase C ( PKC ), c-jun N-terminal kinase ( JNK ), and Src signaling pathways ... We studied the expression of MMP-2 in the presence of PKC isoform-specific inhibitors and found that the PKCdelta inhibitor rottlerin inhibits MIF induced RA synovial fibroblast MMP-2 production
Assunção-Miranda et al., J Med Virol 2010 (Alphavirus Infections...) : The use of different strategies to block MIF action, including an anti-MIF antibody, the MIF inhibitor ISO-1 and knockout mice for the MIF gene, showed that cytokine secretion and MMP expression during infection were regulated by MIF , suggesting that this cytokine acts in autocrine and paracrine manner upstream in the macrophage activation cascade
Park et al., Circ J 2010 (Coronary Artery Disease...) : Plasma levels of matrix metalloproteinase 2 and 9 ( MMP-2, -9 ), tissue inhibitor of metalloproteinase-1, adiponectin, and macrophage migration inhibitory factor were measured
Cavalcanti et al., PloS one 2011 (Ileitis...) : MIF also affected the expression of matrix metalloproteinase-9 (MMP-9) but not MMP-2 in the intestine of infected mice