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RELA — TNIP2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Angiopoietin receptor Tie2-mediated signaling: Tie2/Ang1/ABIN2 complex (ANGPT1-TEK-TNIP2) → NF kappa B/RelA complex (NFKB1-RELA) (modification, activates)
  Hughes et al., Circ Res 2003, Tadros et al., Blood 2003*
  Evidence: mutant phenotype, assay, reporter gene

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of MAP3K8-TNIP2-NFKB1-NFKB2-NFKB2-RELA Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 13 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 16 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 11 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 11 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of RELA-TNIP2-IQGAP2-AKAP8L Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of RELB-REL-TNIP2-NFKB1-RELA-NFKBIA-NFKB2-IKBKG-NFKB1 Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of RELA-PAPOLA-REL-TNIP2 Bouwmeester et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: TNIP2 — RELA (physical association, affinity chromatography technology) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2): TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) complex (CHUK-IKBKG-KPNA3-NFKB1-NFKB2-NFKBIA-NFKBIB-NFKBIE-REL-RELA-RELB-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex: CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex complex (AKAP8L-CHUK-IQGAP2-RELA-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM REL-MAP3K8-RELA-TNIP2-PAPOLA complex: REL-MAP3K8-RELA-TNIP2-PAPOLA complex complex (MAP3K8-PAPOLA-REL-RELA-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex: CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex complex (CHUK-COPB2-IKBKG-NFKB1-NFKB2-NFKBIA-NFKBIE-REL-RELA-SPAG9-TNIP1-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I): TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of AKAP8L-TNIP2-IQGAP2-RELA-CHUK (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of MAP3K8-TNIP2-REL-PAPOLA-RELA (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 18 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 13 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 13 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Dip Interaction: TNIP2 — RELA (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: TNIP2 — RELA (in vitro) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 290 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 145 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 145 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: TNIP2 — RELA (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Ophid Interaction: TNIP2 — RELA (aggregation, confirmational text mining) Bouwmeester et al., Nat Cell Biol 2004
• IRef Ophid Interaction: TNIP2 — RELA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Van Huffel et al., J Biol Chem 2001 : NF-kappaB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2 ... In contrast, NF-kappaB activation by overexpression of IKKbeta or direct activators of the IKK complex, such as Tax, can not be inhibited by ABIN-2
Tadros et al., Blood 2003 : ABIN-2 inhibits nuclear factor-kappaB (NF-kappaB) activity and is a possible effector of A20 regulation of NF-kappaB
Li et al., Biochem Biophys Res Commun 2006 : Overexpression of ABIN-2 , a negative regulator of NF-kappaB , delays liver regeneration in the ABIN-2 transgenic mice ... Our transgenic data demonstrated that overexpression of ABIN-2 inhibited NF-kappaB nuclear translocation, which peaked at around 2-4h post-hepatectomy, and this led to an impairment of the G1/S transition as well as a delay in hepatocyte cell cycle progression of the regenerating liver
Papoutsopoulou et al., Nat Immunol 2006 : In contrast, ABIN-2 deficiency did not affect agonist induced regulation of transcription factor NF-kappaB