Gene interactions and pathways from curated databases and text-mining

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ANG — RELA

Text-mined interactions from Literome

Kranzhöfer et al., Biochem Biophys Res Commun 1999 (Arteriosclerosis...) : This study therefore examined the effect of angiotensin (ANG) II on NF-kappaB activation in monocytic cells, a major cellular component of human atheroma, by electrophoretic mobility shift assay ... Moreover, ANG II stimulated NF-kappaB activation in human monocytes, but not in lymphocytes from the same preparation
Ortego et al., Atherosclerosis 1999 (Coronary Artery Disease...) : Angiotensin II (Ang II) and tumor necrosis factor alpha (TNF-alpha) increased NF-kappaB activity in VSMC ( 2 and 5-fold, respectively )
Ruiz-Ortega et al., Circ Res 2000 : In the present work, we investigated the effect of angiotensin II (Ang II) on NF-kappaB activity in rat vascular smooth muscle cells, evaluating the molecular mechanisms and the specific receptor subtype involved
Ruiz-Ortega et al., Nephrol Dial Transplant 2001 : In cultured VSMCs from wild-type mice, Ang II increased NF-kappaB activity that was partially inhibited by AT1 ( losartan ) and AT2 ( PD123319 ) antagonists
Li et al., Zhonghua Bing Li Xue Za Zhi 2001 : In this project the effect of angiotensin II (Ang II) on NF-kappa B activation and the promotion of PDGF-B mRNA expression in human endothelial cell line ECV304 was studied ... Electrophoretic mobility shift assay, immunofluorescence and immunoelectronic microscope techniques, including confocal microscopy and gold particle labelled electronic microscopy were applied to investigate the mechanism by which Ang II activates NF-kappa B , ECV304 cells were transiently transfected with an NF-kappa B/luciferase reporter gene and catalytically inactive NIK, IKK alpha, IKK beta mutants respectively
Li et al., Chin Med J (Engl) 2002 : To examine the effect of angiotensin II (Ang II) on nuclear factor-kappa B (NF-kappaB) activation in human endothelial cell line ECV304 and the molecular mechanism by which Ang II activates NF-kappaB
Ramana et al., J Biol Chem 2002 : Inhibition of AR in VSMC also prevented the activation of NF-kappa B by basic fibroblast growth factor (bFGF), angiotensin-II (Ang-II) , and platelet derived growth factor ( PDGF-AB )
Fujita et al., Mol Cell Endocrinol 2002 (Hyperglycemia...) : Angiotensin II (Ang II) significantly enhanced DNA binding activity of NF-kappaB under HG ( 25.6 mM ) conditions with an increase in p65 subunit of NF-kappaB, and did it slightly under normal glucose ( NG ; 5.6 mM ) conditions
Zhang et al., Arterioscler Thromb Vasc Biol 2005 (Vasculitis) : We examined the signaling mechanism whereby Ang II activates NF-kappaB in vascular smooth muscle cells ( VSMCs )
Yamagishi et al., Cell Tissue Res 2005 : Ang II significantly induced redox-sensitive transcriptional factor NF-kappaB activation and subsequent monocyte chemoattractant protein-1 expression in human umbilical vein ECs ( HUVEC ), both of which were completely inhibited by PEDF or the anti-oxidant N-acetylcysteine
Zhang et al., Circ Res 2005 : Activation of nuclear factor (NF)-kappaB by angiotensin II (Ang II) plays an essential role in stimulating expression of vascular adhesion molecules, which are essential for vascular inflammation
Wu et al., J Hypertens 2006 : Moreover, Ang II increased the phosphorylation of NF-kappaB inducing kinase (NIK) , and this increase was significantly inhibited by nifedipine
Li et al., Regul Pept 2007 (Liver Cirrhosis, Experimental) : However, the signal transduction mechanism underlying effects of Angiotensin II (Ang II) and Aldosterone ( Aldo ) on Nuclear Factor-kappaB (NF-kappaB) and active protein-1 (AP-1) pathway in hepatic fibrogenesis remains to be fully elucidated
Lee et al., Nephrol Dial Transplant 2007 (Diabetes Mellitus, Experimental...) : COMP-Ang1 mediated inhibition of increased NF-kappaB-DNA binding in nuclear extracts from HUVECs grown in high glucose was significantly blocked by soluble Tie2 receptor-Fc
Shang et al., Am J Physiol Cell Physiol 2008 : Gel shift and chromosomal immunoprecipitation assays confirmed that nuclear factor (NF)-kappaB bound to the scn5a promoter in response to ANG II and H ( 2 ) O ( 2 )
Wei et al., Am J Physiol Endocrinol Metab 2008 (Insulin Resistance) : Moreover, ANG II treatment of L6 myotubes induced NF-kappaB activation and TNF-alpha production and decreased insulin stimulated Akt activation and GLUT-4 glucose transporter translocation to plasma membranes
Voegeli et al., Inflamm Res 2009 : Angiotensin II (Ang II) induces the proinflammatory nuclear factor kappaB (NF-kappaB) in the vasculature
Zhang et al., Biochem Biophys Res Commun 2013 (Atherosclerosis) : The inhibitory effects of Ang- ( 1-7 ) on Ang II-induced VCAM-1 promoter activity and NF-kappaB nuclear translocation were all reversed by the competitive antagonist of Ang- ( 1-7 ) at the Mas receptor ... Our results suggest that Ang- ( 1-7 ) mediates its affects on ECs through the Mas receptor, and negatively regulates Ang II-induced VCAM-1 expression by attenuating nuclear translocation of NF-kappaB