Gene interactions and pathways from curated databases and text-mining

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HMOX1 — MMP1

Text-mined interactions from Literome

Kim et al., Carcinogenesis 2009 (Breast Neoplasms) : Overexpression of HO-1 in the MCF-7 cells caused the induction of MMP-1 expression
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1 , MMP-2 and MMP-3, and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Rousset et al., PloS one 2013 : Interestingly, either HO-1 or CO caused a significant decrease in the expression of MMP-1 and DNA fragmentation of chondrocytes stimulated by IL-1ß