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CSRP1 — NOS2

Text-mined interactions from Literome

Ikeda et al., Cardiovasc Res 2002 (Cardiomyopathy, Dilated...) : We investigated the effects of CRP on iNOS expression and subsequent NO synthesis in rat cardiac myocytes, and the mechanism by which CRP exerts its effects
Sjöholm et al., Lancet 2005 (Arteriosclerosis...) : Subodh Verma and associates ( Circulation 2004 ; 109 : 2058-67 ) recently showed that CRP attenuates the survival, differentiation, and function of endothelial progenitor cells, partly by CRP reducing expression of endothelial nitric-oxide synthase
Xu et al., Mol Endocrinol 2007 (Insulin Resistance...) : Recombinant CRP suppressed insulin induced NO production, inhibited the phosphorylation of Akt and endothelial nitric oxide synthase , and stimulated the phosphorylation of IRS-1 at the Ser307 site in a dose dependent manner
Liu et al., Cell Physiol Biochem 2010 : CRP increased mRNA levels and protein expressions of vascular endothelial growth factor A ( VEGF-A ) and inducible nitric oxide synthase (iNOS) in VSMCs, and enhanced NO secretion in the medium
Tanigaki et al., Diabetes 2013 (Insulin Resistance) : CRP does not impair skeletal muscle glucose delivery in Fc?RIIB ( -/- ) mice or in endothelial nitric oxide synthase knock-in mice with phosphomimetic modification of Ser1176, which is normally phosphorylated by insulin signaling to stimulate nitric oxide mediated skeletal muscle blood flow and glucose delivery and is dephosphorylated by CRP/Fc?RIIB