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NOS2 — TGFB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhang et al., Am J Respir Cell Mol Biol 1999
:
The results show that
TGF-beta(1) caused a virtually complete suppression of IL-1beta induced
iNOS expression while preventing the decline in alpha-SMA expression or the myofibroblast subpopulation
Bogdan et al., Immunol Rev 2000
(Leishmaniasis, Cutaneous) :
During the early phase of infection with the intracellular pathogen Leishmania major, focally expressed
NOS2/NO not only exerts antimicrobial activities but also
controls the function of natural killer cells and the expression of cytokines such as IFN-gamma or
transforming growth factor-beta
Pellacani et al., J Biol Chem 2001
:
The aim of the present study was to determine whether regulation of HMG-I(Y) by
TGF-beta1 contributes to the TGF-beta1 mediated suppression of
NOS2 ... To determine whether the down-regulation of HMG-I(Y) contributed to a decrease in
NOS2 gene
transactivation by
TGF-beta1 , we performed cotransfection experiments ... The
effect of
TGF-beta1 on
NOS2 gene transactivation was not related to a decrease in binding of HMG-I(Y) to the promoter of the NOS2 gene, but due to a decrease in endogenous HMG-I(Y) protein ... This down-regulation of HMG-I(Y) contributes to the
TGF-beta1 mediated decrease in
NOS2 gene transactivation by proinflammatory stimuli
Saura et al., Circ Res 2002
:
Smad2 mediates
transforming growth factor-beta induction of endothelial
nitric oxide synthase expression
Luckhart et al., Infect Immun 2003
(Malaria) :
In a manner analogous to the
regulation of vertebrate
inducible NO synthase and malaria parasite ( Plasmodium ) infection in mammals by
TGF-beta1 , TGF-beta1 regulates AsNOS expression and Plasmodium development in A. stephensi
Chen et al., J Biol Chem 2003
:
In this study, we investigated the role of Ets transcription factors in the
regulation of
NOS2 by LPS and
transforming growth factor (TGF)-beta 1
Schini et al., Eur J Pharmacol 1992
:
The induction of
nitric oxide synthase activity is
inhibited by
TGF-beta 1 , PDGFAB and PDGFBB in vascular smooth muscle cells
Feinberg et al., J Biol Chem 2004
(Arteriosclerosis...) :
Conversely,
TGF-beta1 inhibition of cytokine mediated induction of
iNOS and IL-6 expression was completely blocked in Smad3-deficient VSMCs
Seabra et al., Biochem Biophys Res Commun 2004
(Inflammation) :
TGF-beta1 led to
inducible nitric oxide synthase (iNOS) degradation, actin filament ( F-actin ) depolymerization, and lack of nuclear factor-kappaB (NF-kappaB) in the nucleus
Mitani et al., Nitric Oxide 2005
:
TGF-beta1 decreased iNOS protein amount through enhanced degradation, although
TGF-beta1 did not
affect IFN-gamma induced
iNOS mRNA level or stability ... Because MG132 inhibited iNOS protein degradation and IFN-gamma plus TGF-beta1 treatment increased the trypsin-like activity of proteasomes, we hypothesized that
TGF-beta1 might
enhance iNOS protein degradation via the ubiquitin-proteasome pathway in the presence of IFN-gamma
Boche et al., Neurobiol Dis 2006
(Chronic Disease...) :
In contrast, inhibition of
TGFbeta1 activity using an adenovirus expressing decorin
induces severe cerebral inflammation, expression of inducible
nitric oxide synthase and acute neuronal death in prion diseased animals only
Takaki et al., Genes Cells 2006
:
Using murine macrophage-like cell line RAW 264.7, we demonstrated that
TGF-beta1 not only
reduced the
inducible NO synthase (iNOS) protein stability but also suppressed the iNOS gene transcription ... Thus, multiple mechanisms are present for the
TGF-beta1 mediated reduction of
iNOS production, and we propose a novel mechanism for regulating inflammatory cytokine by an anti-inflammatory cytokine, TGF-beta1 ; i.e. suppression of IFN-gamma induced STAT1 activation by an association of the IFNGR1 with the TGF-betaRI
Vyas-Read et al., Am J Physiol Lung Cell Mol Physiol 2007
:
TGF-beta1 ( 50 pM ) suppressed eNOS expression by more than 60 % and activity by 83 % but did not
affect iNOS expression or activity
Wang et al., Prostate 2007
(Prostatic Neoplasms) :
Expression of both
TGF-beta1 protein and mRNA was
inhibited in both dose- and time dependent manners by NO donors sodium nitroprusside ( SNP ), S-nitroso-N-acetylpenicilamine (SNAP), S-nitrosoglutathione ( GSNO ), and ( +/- ) - ( E ) -methyl-2- [ ( E ) -hydroxyimino ] -5-nitro-6-methoxy-3-hexeneamide ( NOR-1 ) and by transfection of
iNOS ... The inhibitory
effects of SNP and
iNOS on
TGF-beta1 expression were reduced in cells treated with NO scavengers N-dithiocarboxysarcosine ( DTCS ), 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide ( PTIO ), and hemoglobin, or with the iNOS inhibitor N-methyl-arginine ( NMA )
Hamby et al., Prostaglandins Other Lipid Mediat 2008
:
TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and
nitric oxide synthase-2 gene expression in a stimulus independent manner
Saed et al., Wound Repair Regen 2009
(Anoxia...) :
Additionally, silencing
iNOS reduced type I collagen and
transforming growth factor-beta in adhesion fibroblasts, but to a lesser extent in peritoneal fibroblasts
Koide et al., Hypertension 1994
:
These findings suggest that interferon gamma directly induces the expression of the inducible
nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that
transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Stenger et al., J Exp Med 1994
(Leishmaniasis, Cutaneous) :
In the lesions of BALB/c mice, cells staining positively for
transforming growth factor beta ( TGF-beta ), a potent
inhibitor of
iNOS in vitro, were strikingly more prominent than in C57BL/6, whereas no such difference was found for interleukin 4 or interferon gamma (IFN-gamma)
Finder et al., Am J Physiol 1995
:
These results demonstrate that
TGF-beta 1 regulates production of NO in RPASM by inhibiting
iNOS expression in part by increasing degradation of existing iNOS protein
Inoue et al., Arterioscler Thromb Vasc Biol 1995
:
Molecular
regulation of the bovine endothelial cell
nitric oxide synthase by
transforming growth factor-beta 1
Goureau et al., Proc Natl Acad Sci U S A 1993
:
Differential
regulation of inducible
nitric oxide synthase by fibroblast growth factors and
transforming growth factor beta in bovine retinal pigmented epithelial cells : inverse correlation with cellular proliferation
Kleinert et al., J Biol Chem 1996
(Second Messenger Systems) :
Transforming growth factor-beta1 ( which is an inhibitor of NOS II induction in other cell types )
potentiated NOS II mRNA expression produced by all inducing agents listed, whereas dexamethasone, pyrrolidine dithiocarbamate and 3,4-dichloroisocoumarin ( inhibitors of NF-kappaB activation ) suppressed NOS II mRNA induction in response to all stimulants
Perrella et al., Proc Natl Acad Sci U S A 1996
(Hypotension...) :
Thus, we hypothesized that
TGF-beta1 may
inhibit iNOS gene expression in vivo and be beneficial in the treatment of septic shock ... Thus these studies suggest that
TGF-beta1 inhibits
iNOS in vivo and that TGF-beta1 may be of future benefit in the therapy of septic shock
Hamada et al., Neurosci Lett 1996
(Cicatrix...) :
This study was undertaken to examine the
effect of
transforming growth factor-beta 1 ( TGF-beta 1 ) administered into the subarachnoid space after spinal cord injury ( SCI ) on the increased production of
inducible-nitric oxide synthase (i-NOS) in the injured spinal cord in rats
Vodovotz et al., J Exp Med 1996
(Alzheimer Disease) :
In mice,
NOS2 is normally
suppressed by
transforming growth factor beta 1 ( TGF-beta 1 )
Vincent et al., Glia 1997
:
Inhibition of endotoxin induced
nitric oxide synthase production in microglial cells by the presence of astroglial cells : a
role for
transforming growth factor beta
Kuemmerle et al., Am J Physiol 1998
:
The increase in
NOS II activity induced by IL-1 beta and TNF-alpha was
inhibited 73-86 % by
transforming growth factor-beta 1 ( TFG-beta 1 )
Mabley et al., J Endocrinol 1997
:
Transforming growth factor beta 1 prevents cytokine mediated inhibitory effects and induction of
nitric oxide synthase in the RINm5F insulin containing beta-cell line