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IGFBP1 — IL1B

Text-mined interactions from Literome

Frost et al., Endocrinology 2000 : The ability of IL-1beta to stimulate the expression of IGFBP-1 and the phosphorylation of the above kinases was specifically inhibited by PD98059, a MEK-1 inhibitor ... Conversely, a PKA inhibitor ( H-89 ) inhibited the ability of cAMP, but not IL-1beta to stimulate IGFBP-1 synthesis ... Our data demonstrate that the MAP kinase signal transduction pathway plays an important role in the regulation of IGFBP-1 synthesis by IL-1beta
Strakova et al., Endocrinology 2000 : Both dbcAMP and IL-1beta , in the presence of hormones, can independently induce IGFBP-1 gene expression and decidualization
Strakova et al., Endocrinology 2003 (MAP Kinase Signaling System) : We reported that IL-1beta ( 10 ng/ml ) with steroid hormones [ 36 nm estradiol-17beta, 1 microm medroxyprogesterone acetate ( P ), and 100 ng/ml relaxin ] induces in vitro IGFBP-1 synthesis
Strakova et al., Endocrinology 2005 : The most marked effect of IL-1beta was the induction of IGF binding protein-1 protein in stromal cells close to the apical surface, whereas cyclooxygenase-1 was down-regulated in the glandular epithelium
Rutkute et al., Biochem Biophys Res Commun 2007 : Employment of c-Jun N-terminal kinase (JNK) inhibitor SP600125 resulted in 3-fold reduction of IGFBP-1 mRNA and protein levels, indicating that IL-1beta induced IGFBP-1 production is mediated through JNK activation ... Moreover, glutathione depletion in hepatocytes from young rats potently activated JNK, as well as increased IL-1beta induced IGFBP-1 mRNA levels, suggesting that age related oxidative stress underlies the upregulated JNK activation and IGFBP-1 expression