Gene interactions and pathways from curated databases and text-mining

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IL1B — IRF8

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Marecki et al., J Immunol 1999 : Furthermore, both IRF4 and ICSBP activated transcription of the IL-1beta promoter in both cell types
Marecki et al., J Immunol 2001 : Furthermore, coexpression of IRF-1 and IRF-2 dramatically increased the capacity of both PU.1/IRF-4 and PU.1/ICSBP to induce IL-1beta reporter gene expression in fibroblasts
Unlu et al., Mol Immunol 2007 : Phosphorylation of IRF8 in a pre associated complex with Spi-1/PU.1 and non phosphorylated Stat1 is critical for LPS induction of the IL1B gene