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LEP — PTPN1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kaszubska et al., Mol Cell Endocrinol 2002
:
Protein tyrosine phosphatase 1B negatively
regulates leptin signaling in a hypothalamic cell line ... Furthermore, over-expression of
PTP1B led to a decrease in mRNA accumulation of suppressor-of-cytokine-signalling-3 ( SOCS3 ) and c-fos, genes that are acutely
induced by
leptin
Dadke et al., Curr Drug Targets Immune Endocr Metabol Disord 2003
(Diabetes Mellitus, Type 2...) :
In this review, we discuss the
role of
PTP1B in
leptin and insulin signaling, as well as its potential as a drug target in the treatment of obesity
Taylor et al., Expert Opin Investig Drugs 2004
(Diabetes Mellitus...) :
Over the last decade, a considerable body of evidence has been amassed indicating that
protein tyrosine phosphatase 1B (PTP1B) is
involved in the downregulation of insulin and
leptin signalling
Lund et al., J Mol Endocrinol 2005
:
In conclusion, these results suggested that the negative regulatory
role of
PTP1B on
leptin signalling is mediated through a direct and selective dephosphorylation of the two signalling molecules, JAK2 and STAT3
Ren et al., Cell Metab 2005
(Body Weight...) :
Moreover, overexpression of SH2-B counteracted
PTP1B mediated inhibition of
leptin signaling in cultured cells
Bence et al., Nat Med 2006
(Body Weight) :
Furthermore, neuronal
PTP1B regulates adipocyte
leptin production and probably is essential for the development of leptin resistance
Morrison et al., Endocrinology 2007
(Obesity) :
To identify potential cellular mediators of this resistance, we focused on
protein tyrosine phosphatase 1B (PTP1B) , a recently described
inhibitor of
leptin signaling
Kasibhatla et al., Curr Opin Investig Drugs 2007
(Diabetes Mellitus, Type 2) :
Mounting evidence indicates that protein tyrosine phosphatase
(PTP)1B negatively
regulates insulin and
leptin signaling making it a prime target for enhancing insulin sensitivity and controlling body mass
Picardi et al., Endocrinology 2008
(Body Weight...) :
We investigated the
role of hypothalamic
PTP1B in the regulation of food intake, insulin and
leptin actions and signaling in rats through selective decreases in PTP1B expression in discrete hypothalamic nuclei
Benomar et al., Endocrinology 2009
:
Interestingly,
leptin as well as insulin
induced the expression of phosphotyrosine phosphatase
(PTP)-1B , whereas CNTF treatment did not affect its expression
White et al., Am J Physiol Endocrinol Metab 2009
:
However, these data also indicate that
leptin is not
required for the increase in hypothalamic
PTP1B or the development of leptin resistance
Xue et al., Mol Cell Biol 2009
(Body Weight) :
Therefore, the mechanism by which
PTP1B regulates adiposity and
leptin sensitivity likely involves the coordinated regulation of AMPK in hypothalamus and peripheral tissues
Heida et al., Arterioscler Thromb Vasc Biol 2010
(Disease Models, Animal...) :
Protein tyrosine phosphatase 1B , a negative
regulator of
leptin signaling, was overexpressed in CACs from obese, hyperleptinemic individuals, and this was associated with insensitivity of CACs to the angiogenic effects of leptin
Briancon et al., Diabetes 2010
(Insulin Resistance...) :
Suppressor of cytokine signaling (SOCS)-3 and
protein-tyrosine phosphatase 1B (PTP-1B) are two endogenous inhibitors of tyrosine kinase signaling pathways and
suppress both insulin and
leptin signaling via different molecular mechanisms
Haque et al., Cell 2011
:
Protein tyrosine phosphatase 1B (PTP1B) plays important roles in downregulation of insulin and
leptin signaling and is an established therapeutic target for diabetes and obesity
Ito et al., Regul Pept 2012
:
The expression levels of hypothalamic
protein tyrosine phosphatase 1B (PTP1B) , a negative
regulator of
leptin and insulin signaling, are also elevated by HFD, and several lines of evidence support a relationship between TNFa and PTP1B
Owen et al., PloS one 2012
:
Protein tyrosine phosphatase 1B (PTP1B) , a key negative
regulator of
leptin and insulin signaling, is positively correlated with adiposity and contributes to insulin resistance
De Jonghe et al., Am J Physiol Endocrinol Metab 2012
:
POMC neuron-specific deletion of
protein tyrosine phosphatase 1B (PTP1B) ( Ptpn1 ( loxP/loxP ) POMC-Cre ), a negative
regulator of CNS
leptin signaling, results in resistance to diet induced obesity and improved peripheral leptin sensitivity in mice, thus establishing PTP1B as an important component of POMC neuron regulation of energy balance