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CYBA — NCF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases)
  Rinckel et al., Biochem Biophys Res Commun 1999*
  Evidence: Upon stimulation, a functional NADPH oxidase is assembled when the cytosolic proteins, Rac, p67phox, p47phox, and possibly p40phox, associate with the gp91phox and p22phox transmembrane proteins.
• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases, Activity)
  
  Evidence: PKC is known to induce cellular reactive oxygen species (ROS) and PKC-dependent activation of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH oxidase has recently been shown to be responsible, in part, for increased oxidative stress in diabetes.
• KEGG Phagosome: CYBA → NCF1 (protein-protein, binding/association)
• KEGG Leukocyte transendothelial migration: VCAM1 → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 (enzyme-enzyme, activation)
  
• KEGG Leukocyte transendothelial migration: Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 → MMP2/MMP9 (enzyme-enzyme, activation)
• KEGG Leukocyte transendothelial migration: Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 → MAPK11/MAPK12/MAPK13/MAPK14 (enzyme-enzyme, activation)
  
• KEGG Leukocyte transendothelial migration: RAC1 → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 (protein-protein, activation)
  
• KEGG Leishmaniasis: Complex of NCF1-NCF2-NCF4 → Complex of CYBA-NOS2 (protein-protein, dissociation)
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) (modification, collaborate)
  Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → cytochrome b-245 complex (CYBB-CYBA) (modification, collaborate)
  Roepstorff et al., J Biol Chem 2008
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → p47 Phox/p67 Phox complex (NCF1-NCF2) (modification, collaborate)
  Roepstorff et al., J Biol Chem 2008
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: cytochrome b-245 complex (CYBB-CYBA) → p47 Phox/p67 Phox complex (NCF1-NCF2) (modification, collaborate)
  Roepstorff et al., J Biol Chem 2008
  Evidence: physical interaction
• Reactome Reaction: CYBA → NCF1 (indirect_complex)
• WikiPathways Microglia Pathogen Phagocytosis Pathway: NCF4/NCF2/NCF1 → NCF1/NCF4/NCF2/RAC1/RAC2/RAC3/CYBB/CYBA (mim-conversion)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CYBA — NCF1 (direct interaction, pull down) Fontayne et al., Biochemistry 2002*
• IRef Biogrid Interaction: CYBA — NCF1 (direct interaction, pull down) Leto et al., Proc Natl Acad Sci U S A 1994
• IRef Hprd Interaction: CYBA — NCF1 (in vitro) Li et al., J Biol Chem 2002, Leto et al., Proc Natl Acad Sci U S A 1994, de Mendez et al., Mol Cell Biol 1997*
• IRef Hprd Interaction: CYBA — NCF1 (in vivo) Li et al., J Biol Chem 2002, Leto et al., Proc Natl Acad Sci U S A 1994, de Mendez et al., Mol Cell Biol 1997*
• IRef Intact Interaction: CYBA — NCF1 (direct interaction, pull down) Ogura et al., J Biol Chem 2006*
• IRef Intact Interaction: CYBA — NCF1 (direct interaction, nuclear magnetic resonance) Ogura et al., J Biol Chem 2006*
• IRef Intact Interaction: CYBA — NCF1 (direct interaction, far western blotting) Tamura et al., FEBS Lett 2007*
• IRef Intact Interaction: CYBA — NCF1 (direct interaction, biophysical) Ogura et al., J Biol Chem 2006*
• IRef Intact Interaction: CYBA — NCF1 (direct interaction, classical fluorescence spectroscopy) Ogura et al., J Biol Chem 2006*
• IRef Ophid Interaction: CYBA — NCF1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CYBA — NCF1 (aggregation, confirmational text mining) Leto et al., Proc Natl Acad Sci U S A 1994

Text-mined interactions from Literome

Fontayne et al., Biochemistry 2002 : The ability of each PKC isoform to induce p47(phox) to associate with p22(phox) was tested by using an overlay technique ; the results showed that all the PKC isoforms that were studied induce p47(phox) binding to the cytosolic fragment of p22(phox)
Leto et al., Proc Natl Acad Sci U S A 1994 (Granulomatous Disease, Chronic) : Expression of mutated p22-phox did not restore oxidase activity to p22-phox-deficient B cells and did not enable p22-phox dependent translocation of p47-phox to membranes in phorbol ester stimulated cells