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AHSA1 — PPARG
Text-mined interactions from Literome
Puigserver et al., Mol Cell 2001
(Cachexia) :
Cytokine stimulation of energy expenditure through
p38 MAP kinase
activation of
PPARgamma coactivator-1
Schild et al., Placenta 2006
:
Here we tested the hypothesis that
p38 plays an important role in the regulation of
PPARgamma in primary human trophoblasts ... Our data support an
effect of
p38 on
PPARgamma protein stability because p38 inhibition led to reduced expression of PPARgamma protein without a significant effect on PPARgamma mRNA, and this reduction was blocked by the protease inhibitor MG-132 ... Together, these data indicate that
p38 regulates
PPARgamma expression and activity in term human trophoblasts
Stanton et al., J Cell Mol Med 2010
:
PPARgamma2 expression in growth plate chondrocytes is
regulated by
p38 and GSK-3 ...
PPARgamma expression is
suppressed by
p38 activity, but requires GSK-3 activity