Epling-Burnette et al., J Immunol 2001
:
Using either AG-490 or wortmannin alone, we observed a dose dependent inhibition of GM-CSF induced Mcl-1 expression
Derouet et al., J Biol Chem 2004
:
Addition of GM-CSF to neutrophils enhanced Mcl-1 stability and delayed apoptosis by signaling pathways requiring PI3K/Akt and p44/42 Erk/Mek, because inhibitors of these pathways completely abrogated the GM-CSF mediated effect on both Mcl-1 stability and apoptosis delay
Cowburn et al., Am J Respir Cell Mol Biol 2011
(Inflammation...) :
We report that granulocyte/macrophage colony stimulating factor ( GM-CSF ) and tumor necrosis factor (TNF)-a prevent the normal time dependent loss of Mcl-1 and Bcl2A1 in neutrophils, and we demonstrate that they cause an NF-?B dependent increase in Bcl-X ( L ) transcription/translation