Gene interactions and pathways from curated databases and text-mining

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CD44 — IL4

Text-mined interactions from Literome

Kryworuchko et al., Cell Immunol 1999 (Burkitt Lymphoma) : Regulation of CD44-hyaluronan interactions in Burkitt 's lymphoma and Epstein-Barr virus transformed lymphoblastoid B cells by PMA and interleukin-4
Gee et al., Cell Immunol 2001 (Burkitt Lymphoma) : Differential effect of IL-4 and IL-13 on CD44 expression in the Burkitt 's lymphoma B cell line BL30/B95-8 and in Epstein-Barr virus ( EBV ) transformed human B cells : loss of IL-13 receptors on Burkitt 's lymphoma B cells ... In this study, we demonstrate that IL-4 and IL-13 exhibited differential effects on CD23 and CD44 expression and binding to hyaluronan in BL30/B95-8, a Burkitt 's lymphoma ( BL ), and MK3.31, an Epstein-Barr virus transformed normal human B cell line ( B-LCL )
Macdonald et al., Eur J Gastroenterol Hepatol 2003 (Colitis, Ulcerative...) : IL-4 and IL-13 are potent inducers of CD44v6 and CD44v3 expression on colon epithelial cells ... We have identified increased adhesion between lymphocytes and colon epithelial cells caused by IL-4 induced CD44v6 expression
Ibrahim et al., Int J Gynecol Cancer 2006 (Adenocarcinoma...) : The effects of interleukin (IL)-1alpha, IL-1beta, IL-4 , IL-13, transforming growth factor (TGF)-beta1, estrogen, and progestogen on CD44v5 expression were examined in cultures of three human cervical adenocarcinoma cell lines ( HeLa, HeLa229, and HS588T )
Jin et al., J Leukoc Biol 2006 : After activation of B cells with CD40 and LPS, IL-4 and IL-21 distinctively regulated the expression of CD23, CD44 , and CD138, and they cooperatively promoted IgG1 class switching and synthesis
Natesan et al., J Immunol 1996 : CD44low , naive CD4+ T lymphocytes, could only be induced to produce IL-4 by repeated stimulation with B7 transfectants
Trejdosiewicz et al., Cytokine 1998 : All cell lines expressed IL-4 receptors, but IL-4 and IL-13 induced upregulation of CD44 only in the colonic cell lines ... CD44 upregulation in mitogen activated PBL was not increased by IL-4 and IL-13 and was not inhibited by neutralizing antibodies