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GCG — IL6
Text-mined interactions from Literome
Yelich et al., Pancreas 1992
:
Effects of endotoxin and
interleukin-1 on
glucagon and insulin secretion from the perfused rat pancreas
Ellingsgaard et al., Proc Natl Acad Sci U S A 2008
:
The islet
IL-6R is functional, and IL-6 acutely
regulates both pro-glucagon mRNA and
glucagon secretion in mouse and human islets, with no acute effect on insulin secretion
Stith et al., Circ Shock 1994
:
IL-6 produced a transient
increase in plasma
glucagon that was mirrored by elevated plasma glucose and a depletion of hepatic glycogen
Tsigos et al., J Clin Endocrinol Metab 1997
:
In contrast,
IL-6 caused significant increases in plasma
glucagon levels, which peaked between 120 and 150 min after the IL-6 injection
Pailla et al., JPEN J Parenter Enteral Nutr 1998
:
Hepatocyte monolayers were incubated for 6 hours, with either KIC or octanoic acid ( 1 mmol/L ), in the
presence of
glucagon and TNF-alpha ( 25 micro/L ) IL-6 ( 15 microg/L ) and/or
IL-6