Gene interactions and pathways from curated databases and text-mining

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GRB2 — SOS2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chesnel et al., Biol Cell 2003 : We also demonstrate that, like p60 ( Xl ) ( Shc ), Grb2 and the guanine nucleotide exchange factor Sos are expressed in oocytes throughout vitellogenesis and in early embryos and that overexpression of a dominant negative form of Grb2 specifically inhibits insulin induced resumption of meiosis
Goudreau et al., Nat Struct Biol 1994 : GRB2 couples receptor tyrosine kinase activation to Ras signalling by interacting, through its SH3 domains, to the carboxy-terminal proline-rich regions of the guanine nucleotide exchange factor Sos
Buday et al., Cell 1993 (Carcinoma, Squamous Cell) : In vitro reconstitution shows that Grb2 is required for the binding of activated EGF receptor to Sos
Wong et al., J Biol Chem 1996 : Additional experiments indicated that neither the binding of the nucleotide exchange factor Sos to GRB2 nor tyrosine phosphorylation of PTP1D was required for EGF stimulated coupling of PTP1D to GRB2
Zhang et al., Anal Biochem 1996 : Using epidermal growth factor (EGF) receptor, Grb2 and Sos proteins as an example, we demonstrated the use of the three-hybrid system to detect formation of a three-component complex, i.e., the Grb2 mediated interactions between EGF receptor and Sos
Jefferson et al., Oncogene 1998 : Binding of Grb2 to SOS did not prevent the inhibition of SOS by PtdIns4,5P2 suggesting that there must be another mechanism for regulating this inhibition