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HLA-E — IFNG

Text-mined interactions from Literome

Hurks et al., Invest Ophthalmol Vis Sci 2001 (Melanoma...) : Notably, all cell lines expressed HLA-E , and this expression was significantly enhanced by interferon-gamma
Barrett et al., Mol Cell Biol 2004 : We have now identified and characterized a cell type restricted enhancer of IFN-gamma mediated induction of HLA-E gene transcription, designated the upstream interferon response region ( UIRR ), which is located immediately upstream of the IRR ... The UIRR mediates a three- to eightfold enhancement of IFN-gamma induction of HLA-E transcription in some cell lines but not in others, and it functions only in the presence of an adjacent IRR ... Forced expression of GATA-1 in nonexpressing U937 cells resulted in a four- to fivefold enhancement of the IFN-gamma response from HLA-E promoter constructs containing a wild-type but not a GATA-1 mutant UIRR sequence and increased the IFN-gamma response of the endogenous HLA-E gene ... Knockdown of GATA-1 expression in K562 cells resulted in a approximately 4-fold decrease in the IFN-gamma response of the endogenous HLA-E gene, consistent with loss of the increase in IFN-gamma response of HLA-E promoter-driven constructs containing the UIRR in wild-type K562 cells ... We propose that the GATA-1 transcription factor represents a cell type restricted mediator of IFN-gamma induction of the HLA-E gene
Salerno-Gonçalves et al., J Immunol 2004 : These results demonstrate that HLA-E binds nonamer peptides derived from bacterial proteins and trigger CD8+ mediated lysis and IFN-gamma production when exposed to infected targets, raising the possibility that this novel effector mechanism might contribute to host defense against intracellular bacterial infections
Derré et al., J Immunol 2006 (Disease Susceptibility...) : IFN-gamma significantly increased the surface expression of HLA-E and the shedding of soluble HLA-E by these cells, in a metalloproteinase dependent fashion
Browne et al., J Immunol 2006 : In contrast with HLA-A, IFN-gamma induced expression of the HLA class Ib gene, HLA-E , was not affected by either 5'-methyl-5'-thioadenosine or leptomycin B ... These results provide proof of principle that it is possible to differentially modulate the IFN-gamma induced expression of the HLA-E and HLA-A genes, whose products often mediate opposing effects on cellular immunity to tumor cells, pathogens, and autoantigens
Coupel et al., Blood 2007 (Vasculitis) : We demonstrate that tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and interferon gamma (IFNgamma) up-regulate the cell-surface expression of HLA-E on ECs in vitro and induce the release of soluble HLA-E ( sHLA-E )
Levy et al., Int J Oncol 2008 (Carcinoma...) : Moreover, we analysed HLA-E expression in several colorectal cancer cell lines and demonstrated that IFN-gamma upregulates the expression of membrane HLA-E in vitro
Nguyen et al., Bone Marrow Transplant 2009 (Leukemia, Myeloid, Acute) : We show that IFN-gamma produced by immature CD56 ( bright ) NK cells upregulates cell surface expression of HLA-E on AML blasts and that this upregulation protects leukemic cells from NK-mediated cell lysis through the mediation of CD94/NKG2A, an inhibitory receptor overexpressed on NK cells after haploidentical SCT
Weiss et al., Transplantation 2009 : Further, HLA-E/hubeta2m expression on porcine endothelial cells inhibited the secretion of interferon (IFN)-gamma by co-cultured human NK cells