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MCAT — SETD2

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Zhang et al., J Neurosci Res 2005 (Brain Infarction...) : These studies reveal that the pattern of regulation of MCT1 expression after MCAO is similar to that observed previously for glucose transporter 1 (GLUT1) and suggest that the regulation of MCT1 mRNA expression is mediated by the hypoxia-inducible transcription factor HIF1
Sonveaux et al., PloS one 2012 (Neoplasms...) : Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate induced HIF-1 activation and tumor angiogenesis
Chiche et al., Ann Endocrinol (Paris) 2013 : We reported that targeting these pHi regulated processes through inhibition of either HIF-1 induced CAIX/CAXII or HIF-1 induced MCT4 , MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis generated ATP levels and tumor growth