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KDR — S1PR1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: KDR → S1PR1 (increases)
  Evidence: Table II online. Stable knock-down of S1P1 leads to reduced expression of endothelial specific transcripts. The table lists transcripts characteristic for endothelial cells that were downregulated at least two-fold in S1P1-knock-down AS-M.5 cells, as detected by microarray analyses using 22,238 human gene probes. The values indicate signal intensities of two independent analyses for AS-M.5 and AS-M.5, T2, Sil#1, cl.3 and one analysis for AS-M.5, Silco and AS-M.5, T2, Sil#1, cl.2. Where appropria...
• NCI Pathway Database S1P1 pathway: VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) → S1P1 (S1PR1) (transcription, activates) Igarashi et al., Proc Natl Acad Sci U S A 2003*
  Evidence: reporter gene, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: KDR — S1PR1 (interaction, mapped from kegg_pathways)
• STRING interaction: S1PR1 — KDR (interaction, mapped from bind mint intact)