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Bernatchez et al., Br J Pharmacol 2001 : 2. Using specific inhibitors and Western blot analysis, we herein report that in bovine aortic endothelial cells ( BAEC ), VEGF induces the synthesis of PAF through the cascade activation of Flk-1 receptor, phospholipase Cgamma ( PLCgamma ), protein kinase C ( PKC ) and p42/44 mitogen activated protein kinases ( MAPK )
Rechka et al., Can J Physiol Pharmacol 2010 : We previously reported that VEGF mediated PAF synthesis involves the activation of the homodimeric tyrosine kinase receptor VEGFR-2/R-2 , leading to the recruitment of p38 and p42/p44 mitogen activated protein kinases ( MAPKs ) and activation of secreted group V phospholipase A2 ( sPLA2-V )