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LRPAP1 — TERF1
Text-mined interactions from Literome
McLeod et al., J Immunol 2002
:
Moreover, blocking the
activation of
Rap1 and Rap2 via the expression of a
Rap-specific GTPase activating protein significantly reduced the ability of B cells to migrate toward SDF-1
Nagashima et al., Mol Biol Cell 2002
:
In contrast,
rap1GAPII , a negative
regulator of
Rap1 , did not inhibit ephrin-B1 induced membrane ruffling
Rong et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
These observations indicate that the lipase activity of PLC-gamma1 mediates NGF regulated MAPK signaling upstream of
Ras/Rap1 activation probably through second messenger DAG activated Ras and
Rap-GEFs
Dong et al., Endocr Relat Cancer 2011
(Adenocarcinoma, Follicular...) :
Histone deacetylase inhibitors upregulate
Rap1GAP and
inhibit Rap activity in thyroid tumor cells
Vuchak et al., Cell Adh Migr 2011
(Colonic Neoplasms) :
In previous studies we demonstrated that silencing
Rap1GAP expression in human colon cancer cells
resulted in sustained increases in
Rap activity, enhanced spreading on collagen and the weakening of cell-cell contacts