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FOXP3 — IL1B

Text-mined interactions from Literome

O'Sullivan et al., J Immunol 2006 (Diabetes Mellitus, Type 1...) : IL-1beta drives proliferation and cytokine production by CD4 ( + ) CD25 ( + ) FoxP3 ( - ) effector/memory T cells, attenuates CD4 ( + ) CD25 ( + ) FoxP3 ( + ) regulatory T cell function, and allows escape of CD4 ( + ) CD25 ( - ) autoreactive effectors from suppression
Kimura et al., Proc Natl Acad Sci U S A 2007 : We demonstrate here that IL-6, but not TNF-alpha or IL-1beta , can, in combination with TGF-beta, induce Th17 cell generation from naïve T cells and inhibit TGF-beta induced Foxp3 expression
Deknuydt et al., Clin Immunol 2009 : Conversion of Treg into T ( H ) 17 cells was induced by IL-1beta and involved down-regulation of the Treg lineage transcription factor FOXP3 and suppressive functions