◀ Back to PARP1
PARP1 — PARP12
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Besson et al., Free radical research 2003
(Brain Diseases) :
The
PARP inhibitor, 3-aminobenzamide, significantly reduced the lesion and
inhibited PARP-1 activation induced by malonate
Xiao et al., J Pharmacol Exp Ther 2005
(Aortic Diseases...) :
The catalytic activity of
PARP was
inhibited by the potent isoindolinone based PARP inhibitor INO-1001 or by
PARP-1 genetic deficiency
Tapodi et al., J Biol Chem 2005
(Necrosis) :
To clarify the molecular mechanism of cytoprotection,
PARP activity was
inhibited pharmacologically by suppressing
PARP-1 expression by a small interfering RNA ( siRNA ) technique or by transdominantly expressing the N-terminal DNA binding domain of PARP-1 ( PARP-DBD ) in cultured cells
Kedar et al., DNA repair 2008
:
Interaction between
PARP-1 and ATR in mouse fibroblasts is
blocked by
PARP inhibition
Choi et al., Hypertension 2012
(Body Weight...) :
Interestingly,
PARP-1 inhibitors significantly reduced the potentiation of myogenic tone, improved endothelium dependent relaxation, restored endothelial NO synthase phosphorylation and cGMP, and
attenuated cleaved
PARP-1
Schiewer et al., Cancer Discov 2012
(Disease Progression...) :
It was further confirmed in genetically defined systems that
PARP-1 supports AR transcriptional function, and that in models of advanced prostate cancer,
PARP-1 enzymatic activity is
enhanced , further linking PARP-1 to AR activity and disease progression
King et al., J Biol Chem 2012
:
PARP activation following UVR exposure
promotes association between
PARP-1 and XPA, a central protein in NER
Tentori et al., Int J Oncol 2013
:
Remarkably, inhibition of
PARP function by PARPi or by PARP-1 gene silencing always increased the antitumor activity of irinotecan, even in the
presence of low
PARP-1 expression
Jog et al., Cell death & disease 2013
:
Although
PARP-1 was activated in both male and female mice,
PARP-1 inhibition
reduced necrosis only in the male mice