◀ Back to CD40
AKT1 — CD40
Text-mined interactions from Literome
Davies et al., Mol Cell Biol 2005
:
Interestingly, whereas the TRAF6 interacting membrane-proximal domain of CD40 has a minor role in signal transduction, studies utilizing TRAF6 knockout fibroblasts and RNA interference in epithelial cells reveal that the
CD40 induced
activation of NF-kappaB, JNK, p38, and
Akt requires the integrity of TRAF6
Aiba et al., Immunity 2006
:
Together, our findings suggest that BANK attenuates
CD40 mediated
Akt activation, thereby preventing hyperactive B cell responses
Benson et al., Eur J Immunol 2006
:
In contrast, CD40 rescue was completely abrogated in TRAF6-deficient B cells, which showed reduced activation of
Akt in
response to
CD40 engagement
Park et al., Nat Biotechnol 2006
(Lymphoma...) :
Lipopolysaccharide or
CD40 signaling
stabilizes Akt1 , promoting both activation and Bcl-2 dependent survival of DCs
Chakrabarti et al., J Biol Chem 2007
(Inflammation) :
These data support a mechanism whereby redox-sensitive
CD40-CD40L interactions
induce activation of
Akt and p38 MAPK, leading to stimulation of NFkappaB and enhanced synthesis of CD40L and MCP1
Lam et al., J Biol Chem 2007
:
Leptin
induces CD40 expression through the activation of
Akt in murine dendritic cells
Lee et al., Journal of cell communication and signaling 2007
:
We found that
CD40 activated JNK, p38, and
Akt via redox dependent pathways that were sensitive to ROS depletion by NAC and ebselen ... The differential requirement for ROS in the
activation of ERK, JNK, p38, and
Akt by the BCR,
CD40 , and CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases, only some of which may be regulated in a redox dependent manner
Riol-Blanco et al., Nat Immunol 2009
:
Direct stimulation of the IS component
CD40 on DCs
leads to the activation of
Akt1 , suggesting the involvement of this receptor in the antiapoptotic effects observed upon IS formation
Pallier et al., Kidney Int 2010
:
This phenotype was associated with the following specific characteristics which include an inhibitory signal ( decreased FcgammaRIIA/FcgammaRIIB ratio ) ; a preventive signal of hyperactive B-cell response ( an increase in BANK1, which negatively modulates
CD40 mediated
AKT activation ) ; an increased number of B cells expressing CD1d and CD5 ; an increased BAFF-R/BAFF ratio that could explain why these patients have more peripheral B cells ; and a specific autoantibody profile
Nadiri et al., Eur J Immunol 2011
:
As to the biological outcomes of the CD40/lipid raft association, we show that disrupting lipid raft integrity selectively abolishes
CD40 mediated
Akt phosphorylation ... In addition, replacing the transmembrane domain of CD40 with that of CD45 ( a protein excluded from lipid rafts ) dramatically reduced
CD40 mediated
Akt phosphorylation and B7.1 upregulation, while not influencing p38, ERK and JNK activation
Tsuji et al., Int Immunopharmacol 2012
:
Bucillamine inhibits
CD40 mediated
Akt activation and antibody production in mouse B-cell lymphoma ... SA981 at a concentration of 30 µM attenuated
CD40 mediated
Akt phosphorylation, but not p38MAPK or I?Ba phosphorylation