Gene interactions and pathways from curated databases and text-mining

◀ Back to CXCL11

CXCL11 — TLR3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CXCL11 → TLR3 (increases, TLR3 Translocation, CXCL11 Activity)
    Evidence: Poly(I:C), an analog of viral dsRNA and a TLR3 ligand,

Text-mined interactions from Literome

Proost et al., J Leukoc Biol 2004 (Arthritis, Infectious...) : In vitro, IFN-gamma and TLR3 ligation by double stranded RNA ( dsRNA ) induced the expression of CXCL9 and CXCL11 in leukocytes and skin-muscle fibroblasts, whereas ligation of TLR2, TLR4, TLR5, and TLR9 by peptidoglycan ( PGN ), lipopolysaccharide (LPS), flagellin, and unmethylated CpG oligonucleotides, respectively, did not ... In sharp contrast, in fibroblasts, the TLR ligands PGN, dsRNA, LPS, and flagellin synergized with IFN-gamma for the production of CXCL9 and CXCL11
Rudd et al., J Virol 2005 : Targeting the expression of TLR3 with small interfering RNA decreased synthesis of IP-10/CXCL10 and CCL5 but did not significantly reduce levels of CXCL8
Wang et al., Blood 2008 : We and others have reported that Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances IL-8 ( CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., Cell Microbiol 2009 : In addition, TLR2 , Dectin-1 and, to an extent, TLR4 are essential for the MU-mediated expression of CXCL8 , CCL2 and LL-37 in keratinocytes
Sharma et al., J Leukoc Biol 2013 : Our findings reveal a previously unrecognized role for S1P in regulating TLR induced CXCL8 secretion from human T cells