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CXCL11 — TLR3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CXCL11
→
TLR3
(increases, TLR3 Translocation, CXCL11 Activity)
Evidence: Poly(I:C), an analog of viral dsRNA and a TLR3 ligand,
Text-mined interactions from Literome
Proost et al., J Leukoc Biol 2004
(Arthritis, Infectious...) :
In vitro, IFN-gamma and
TLR3 ligation by double stranded RNA ( dsRNA )
induced the expression of CXCL9 and
CXCL11 in leukocytes and skin-muscle fibroblasts, whereas ligation of TLR2, TLR4, TLR5, and TLR9 by peptidoglycan ( PGN ), lipopolysaccharide (LPS), flagellin, and unmethylated CpG oligonucleotides, respectively, did not ... In sharp contrast, in fibroblasts, the
TLR ligands PGN, dsRNA, LPS, and flagellin
synergized with IFN-gamma for the production of CXCL9 and
CXCL11
Rudd et al., J Virol 2005
:
Targeting the expression of
TLR3 with small interfering RNA decreased synthesis of IP-10/CXCL10 and CCL5 but did not significantly
reduce levels of
CXCL8
Wang et al., Blood 2008
:
We and others have reported that
Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment
enhances IL-8 (
CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., Cell Microbiol 2009
:
In addition,
TLR2 , Dectin-1 and, to an extent, TLR4 are
essential for the MU-mediated expression of
CXCL8 , CCL2 and LL-37 in keratinocytes
Sharma et al., J Leukoc Biol 2013
:
Our findings reveal a previously unrecognized role for S1P in regulating
TLR induced
CXCL8 secretion from human T cells