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FRS2 — MAPK4

Text-mined interactions from Literome

Kornmann et al., Gastroenterology 2002 (Cell Transformation, Neoplastic...) : In vitro, TAKA-1 cells stably transfected with FGFR-1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of FGFR substrate-2 (FRS2) , Shc, and phospholipase Cgamma ; and increased activation of mitogen activated protein kinase ( MAPK )
Wu et al., Biol Chem 2003 : Upon EGF stimulation, FRS2 mediates enhanced MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues ... Upon EGF stimulation, FRS2 mediates enhanced MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues
Yokote et al., Proc Natl Acad Sci U S A 2005 : Moreover, both receptors stimulate tyrosine phosphorylation of the docking protein FRS2alpha and induce mitogen activated protein kinase stimulation with a time course and intensity that depends on the ligand that is applied
Easton et al., J Neurochem 2006 (Neuroblastoma) : In addition to Shc, fibroblast growth factor receptor substrate 2 (FRS2) is required for the BDNF induced activation of MAPK