Mendez et al., J Neurochem 1999
:
In contrast, activation of 5-HT1A receptors stimulated only a 2.8-fold maximal activation of ERK2 in transfected cells expressing receptors at 300 fmol/mg of membrane protein but did stimulate a 12-fold increase in activity in cells expressing receptors at 3,000 fmol/mg of membrane protein
Adayev et al., Biochim Biophys Acta 2003
:
A selective inhibitor of phospholipase Cbeta ( PLCbeta ) ( U73122 ) but not a general protein kinase C ( PKC ) inhibitor ( GFX ) reversed the 5-HT(1A)-R mediated ERK1/2 stimulation
Zhong et al., Mol Cell Neurosci 2008
(MAP Kinase Signaling System) :
Concomitantly, the effect of 5-HT ( 2A/C ), but not 5-HT(1A) , on ERK activation was abolished in stressed animals