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IFNG — MYC
Text-mined interactions from Literome
Dey et al., J Cell Biochem 1999
:
To understand the antiproliferative signaling of IFNgamma, we studied the
effect of
IFNgamma on expression of
c-Myc , Mad1, Max, cyclin D1, and cyclin D2 genes in both a macrophage cell line and in primary bone marrow derived macrophages ( BMM ) in response to colony stimulating factor-1 (CSF-1) ... We found that whereas
IFNgamma inhibits CSF-1 stimulated
c-Myc gene expression, it induces Mad1 expression
Asao et al., J Biol Chem 2000
:
Interestingly, both IL-3 and
IFN-gamma induce expression of the
c-Myc gene that is not dependent on the Stat1 activity
Söderberg et al., Nat Methods 2006
:
We used this method to show specific regulation of protein-protein interactions between endogenous
Myc and Max oncogenic transcription factors in
response to
interferon-gamma (IFN-gamma) signaling and low-molecular-weight inhibitors