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NOS1 — RAC1
Text-mined interactions from Literome
Gonzalez et al., J Biol Chem 2006
:
Taken together, these studies identify G protein betagamma subunits, Src kinase and the GEF Tiam1 as upstream modulators of S1P mediated Rac1 activation, and establish a central
role for
Rac1 in S1P mediated activation of PI 3-kinase/Akt/endothelial
nitric-oxide synthase signaling in vascular endothelial cells
Sawada et al., Circ Res 2008
(Disease Models, Animal...) :
Regulation of endothelial
nitric oxide synthase and postnatal angiogenesis by
Rac1
Godfrey et al., Exp Cell Res 2010
:
However, increased activation of the GTPase
Rac1 , an early step in agrin signaling, was
dependent on
NOS activity and was mimicked by NO donors and a cGMP analog