Gene interactions and pathways from curated databases and text-mining

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NOS1 — RAC1

Text-mined interactions from Literome

Gonzalez et al., J Biol Chem 2006 : Taken together, these studies identify G protein betagamma subunits, Src kinase and the GEF Tiam1 as upstream modulators of S1P mediated Rac1 activation, and establish a central role for Rac1 in S1P mediated activation of PI 3-kinase/Akt/endothelial nitric-oxide synthase signaling in vascular endothelial cells
Sawada et al., Circ Res 2008 (Disease Models, Animal...) : Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1
Godfrey et al., Exp Cell Res 2010 : However, increased activation of the GTPase Rac1 , an early step in agrin signaling, was dependent on NOS activity and was mimicked by NO donors and a cGMP analog