◀ Back to MUC5AC

MUC5AC — SP1

Text-mined interactions from Literome

Perrais et al., J Biol Chem 2002 (Carcinoma, Squamous Cell...) : Finally, we demonstrate that transcription factor Sp1 not only binds and activates MUC2 and MUC5AC promoters but also participates to their EGF- and TGF-alpha mediated up-regulation
Jonckheere et al., Biochem J 2004 (Neoplasms, Glandular and Epithelial) : Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1
Kato et al., Int J Oncol 2006 (Carcinoma, Pancreatic Ductal...) : Our studies indicate that Sp1 is involved in basal MUC5AC promoter activity while AP-1 is involved in basal and PMA induced MUC5AC promoter activation in pancreatic cancer cells
Di et al., J Biol Chem 2012 (Pulmonary Disease, Chronic Obstructive) : Cigarette smoke induces MUC5AC protein expression through the activation of Sp1 ... Together, these data indicate that CS induces MUC5AC gene transcription predominantly through increased Sp1 nuclear protein levels and increased Sp1 binding to its promoter region