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Florio et al., Mol Endocrinol 2001 : The activation of the phosphotyrosine phosphatase eta ( r-PTP eta ) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation ... Somatostatin highly increased r-PTP eta activity in PCCl3 and PC mos/PTP eta ( +300 %, P < 0.01 ) but not in PCmos cells ... The activation of r-PTP eta by somatostatin caused, acting downstream of MAPK kinase, an inhibition of insulin induced ERK1/2 activation with the subsequent blockade of the phosphorylation, ubiquitination, and proteasome degradation of the cyclin dependent kinase inhibitor p27 ( kip1 ) ... In conclusion, somatostatin inhibition of PC Cl3 cell proliferation requires the activation of r-PTP eta which, through the inhibition of MAPK activity, causes the stabilization of the cell cycle inhibitor p27 ( kip1 )
Florio et al., Minerva Endocrinol 2001 : [ The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PCCl3 thyroid cell proliferation ]
Massa et al., Ann N Y Acad Sci 2004 (Brain Neoplasms...) : The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2