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CASP1 — HRK
Text-mined interactions from Literome
Putcha et al., Neuron 2003
:
Trophic factor deprivation ( TFD ) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1 dependent transactivation of the BH3-only BCL-2 proteins BIM ( EL ) and
HRK , which in turn are critical for BAX dependent cytochrome c release,
caspase activation , and apoptosis
Pyrzynska et al., Mol Oncol 2013
(Glioma) :
Consistently, APPL2 overexpression reduces expression of
HRK and
caspase activation in cells treated with apoptosis inducers, resulting in the enhancement of cell viability