◀ Back to PI3

PAK1 — PI3

Text-mined interactions from Literome

Chaudhary et al., Curr Biol 2000 : Furthermore, integrin induced activation of the serine/threonine kinase Pak-1 , which has been shown to phosphorylate Raf1 Ser338, was also dependent on PI 3-kinase activity and expression of a kinase-inactive Pak-1 mutant blocked phosphorylation of Raf1 Ser338
Diakonova et al., Mol Biol Cell 2002 : The PI 3-kinase inhibitor wortmannin did not change the dynamics of PI 3-kinase or ezrin localization but prevented the loss of PAK1 from phagosomes
Menard et al., Cell Signal 2003 : Activation of PAK1 by LPA was independent of PI3-kinase and the EGF receptor, but was inhibited by dominant negative RhoA
Jung et al., Eur J Biochem 2004 (Melanoma) : Treatment of human melanoma cells A2058 with LPA increased phosphorylation and activation of PAK1 , which was blocked by treatment with pertussis toxin and by inhibition of phosphoinositide 3-kinase (PI3K) with an inhibitor LY294002 or by overexpression of catalytically inactive mutant of PI3Kgamma, indicating that LPA induced PAK1 activation was mediated via a Gi protein and the PI3Kgamma signaling pathway
Mao et al., J Mol Cell Cardiol 2008 (Hypertrophy) : Both Pak1 and Akt can be activated by multiple hypertrophic stimuli or growth factors in a phosphatidylinositol-3-kinase (PI3K) dependent manner
Jones et al., J Biol Chem 1998 : Similarly, immune complex activation of the Rac/Cdc42 dependent serine/threonine kinase Pak1 is blocked by PI 3-kinase inhibitors, but fMLP induced activation is not