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AHSA1 — CASP2
Text-mined interactions from Literome
Whitacre et al., Clin Cancer Res 2000
(Colonic Neoplasms) :
Our results suggest that : ( a ) Pc 4-PDT is effective in the treatment of SW480 human colon cancer xenografts independent of p53 status ; ( b ) PARP cleavage may be
mediated by
caspase-9 and caspase-3 activation in the Pc 4-PDT treated tumors ; and ( c )
p38 phosphorylation may be a trigger of apoptosis in response to PDT in vivo in this tumor model
McLaughlin et al., J Neurosci 2001
:
Indeed, an early robust increase in TEA-sensitive potassium channel currents induced by DTDP is attenuated by
p38 inhibition but not by
caspase inhibition
Baudhuin et al., Mol Pharmacol 2002
:
LPA/S1P induced Akt activation may be involved in cell survival, because LPA and S1P treatment in HEY ovarian cancer cells results in a decrease in paclitaxel induced
caspase-3 activity in a
PI3-K/MEK/p38 dependent manner
Tuo et al., Life Sci 2004
(MAP Kinase Signaling System) :
The opposing effects of onychin on phosphorylation levels of
p38MAPK and ERK1/2, and its
caspase-3 inhibition might play a role in the beneficial effect of onychin on endothelial injury
Guo et al., World J Gastroenterol 2005
:
Since
p38 phosphorylation induced by TGF-beta1
plays an important role in
caspase activation and apoptosis, TPA and EGF induced p38 phosphorylation may not be requisite for their anti-apoptotic function
Shih et al., Food Chem Toxicol 2005
(Adenocarcinoma...) :
In addition, the malvidin treatment significantly increased the p38 kinase expression and inhibited the ERK activity, and the effects of malvidin on
caspase-3 activation were
blocked , respectively, by the ERK and
p38 inhibitors
Friis et al., J Physiol 2005
(Mechanotransduction, Cellular) :
Inhibition of
p38 in Rac cells
reduced the activation of both p53 and
caspase-3
Singh et al., Neuroscience 2005
(Nerve Degeneration) :
Tat induced increases in
caspase-3 activity were significantly
attenuated by an inhibitor of c-jun-N-terminal kinase ( anthra [ 1,9-cd ] pyrazol-6 ( 2H ) -one ), but not by an inhibitor of
p38 ( [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsul-finylphenyl ) -5- ( 4-pyridyl ) 1 H-imidazole ] ), mitogen activated protein kinase
Baek et al., Biol Pharm Bull 2006
(Osteoarthritis) :
Also, Aralia cordata inhibited the chondrocyte apoptosis through the downregulation of JNK and
p38 MAP kinase signal, and the
inhibition of
caspase-3 activity
Hormi-Carver et al., Am J Physiol Gastrointest Liver Physiol 2007
(Barrett Esophagus...) :
Inhibition of
p38 also
prevented expression of cleaved
caspase-3 , suggesting that ATRA activates p38 upstream of the caspase cascade
Ohta et al., J Cell Physiol 2007
(Anoxia...) :
Inhibition of
p38 suppressed activation of
caspase-3 but not vice versa
Fan et al., Mol Cells 2007
:
Suppression of
p38 activation by SB203580 reduced the extent of apoptosis of the HeLa cells and also
prevented induction of p21, release of cytochrome c, and cleavage of
caspase-3 and PARP
Park et al., Exp Mol Med 2007
:
Although 6-OHDA increased phosphorylation of p38 was prevented by NAC or BAPTA, inhibition of
p38 by SB203580 did not suppress ROS, Bax/Bcl-2 ratio, or
caspase-3 activity
increases , and only partially prevented 6-OHDA induced cell death, thus demonstrating that p38 activation is a component of a signaling pathway leading to the initiation of 6-OHDA induced cell death, which acts in parallel with an ROS-Ca ( 2+ ) -Bcl-2-caspase-3 pathway
Roesslein et al., Anesth Analg 2008
(Inflammation) :
Our data suggest that sevoflurane induced
p38 activation is not
affected by
caspase activation
Mitsiades et al., Cancer Res 2008
(Multiple Myeloma) :
Mechanistically, a short in vitro exposure to Aplidin induces MM cell death, which involves activation of
p38 and c-jun NH ( 2 ) -terminal kinase signaling, Fas/CD95 translocation to lipid rafts, and
caspase activation
Eguchi et al., Proteomics 2008
(Anoxia) :
Although some of these proteins decreased after hypoxia, none of them met the conditions of being quantitatively restored by
p38 inhibition but not by
caspase inhibition
Lu et al., Clin Exp Pharmacol Physiol 2009
(Osteosarcoma) :
4. The results of the present study suggest that, in MG63 human osteosarcoma cells, desipramine causes Ca ( 2+ ) -independent apoptosis by inducing
p38 MAPK associated
activation of
caspase 3
Walker et al., International journal of environmental research and public health 2010
(Lung Neoplasms) :
Furthermore, arsenic trioxide modulated
caspase 3 activity and
induced p38 MAP kinase activation in A549 cells
Zhang et al., Environ Toxicol 2013
:
Moreover, a JNK inhibitor, but not
p38 inhibitor, significantly
reduced caspase-3 activation
Bulzomi et al., J Cell Physiol 2012
:
p38 activation is
responsible for pro-apoptotic activation of
caspase-3 and the cleavage of poly ( ADP-ribose ) polymerase