Kuwano et al., Free Radic Biol Med 2008
:
Interleukin-1beta, flagellin, interferon-gamma, and tumor necrosis factor alpha (TNF-alpha) similarly induced Nox1 in a colon cancer cell line ( T84 ), whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold ... Serial mutation analysis of the elements identified an AP-1 binding site ( from -561 to -551 bp, agtAAGtcatg ) as a crucial element for TNF-alpha stimulated transcription of the human NOXO1 gene, which was also confirmed by the AP-1 decoy experiments
Kamizato et al., J Gastroenterol 2009
(Colitis) :
IL-10 also inhibited TNF-alpha stimulated induction of NOXO1 and p38 MAPK phosphorylation