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AKT2 — S1PR1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Waeber et al., Drug News Perspect 2004
:
Finally, S1P also protects endothelial cells from apoptosis through
activation of phosphatidylinositol
3-kinase/Akt/eNOS via
S1P(1) and S1P(3) receptors
Lee et al., Histochem Cell Biol 2006
:
In this report, we describe that S1P stimulated cortactin translocation to the cell periphery to form lamellipodia is specifically mediated by the endothelial S1P1 G-protein coupled receptor, and is regulated by G ( i ) -mediated
Akt dependent
S1P1 receptor phosphorylation and Cdc42/Rac activation pathways
Singleton et al., Circ Res 2009
(Disease Models, Animal...) :
Silencing ( small interfering RNA )
Akt expression
blocked OxPAPC mediated
S1P(1) activation ( threonine phosphorylation ), whereas silencing S1P(1) receptor expression blocked OxPAPC mediated Tiam1 recruitment to CEMs, Rac1 activation, and EC barrier enhancement