Tippin et al., Drug Metab Dispos 2003
:
CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans
Miyoshi et al., Eur J Pharmacol 2005
:
These findings suggest that TNF-alpha plays a key role in endotoxin induced down-regulation of hepatic P-glycoprotein, as well as plays a protective role in the regulation of hepatic CYP3A2 and CYP2C11 against endotoxin induced acute inflammatory response
Shimamoto et al., J Vet Med Sci 2012
(Babesiosis) :
Since TNF-a is one of the potent mediators that induce NOS2 and repress CYP3A transcription, the possible involvement of TNF-a in this downregulation of CYP3A was discussed