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SREBF1 — SREBF2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Field et al., J Biol Chem 2001
:
It is postulated that under basal conditions,
SREBP-1c regulates intestinal fatty acid synthesis and
SREBP-2 regulates cholesterol synthesis
Rishi et al., J Biol Chem 2004
:
EMSA assays demonstrate that
A-SREBP-1 can
inhibit the DNA binding of either B-SREBP-1 or
B-SREBP-2 in an equimolar competition but does not inhibit the DNA binding of the three B-HLH-ZIP proteins MAX, USF, or MITF, even at 100 molar eq. Chimeric proteins containing the HLH domain of SREBP-1 and the leucine zipper from either MAX, USF, or MITF indicate that both the HLH and leucine zipper regions of SREBP-1 contribute to its dimerization specificity