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NPBWR1 — NPW

Pathways - manually collected, often from reviews:

• Reactome Reaction: NPBWR1 → NPW (direct_complex) Tanaka et al., Proc Natl Acad Sci U S A 2003*, O'Dowd et al., Genomics 1995*
• Reactome Reaction: NPBWR1 → NPW (reaction) Tanaka et al., Proc Natl Acad Sci U S A 2003*, Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, O'Dowd et al., Genomics 1995*, Takami et al., Brain Res Mol Brain Res 1994

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NPW — NPBWR1 (direct interaction, pull down) Brezillon et al., J Biol Chem 2003*
• IRef Hprd Interaction: NPW — NPBWR1 (in vitro) Shimomura et al., J Biol Chem 2002*, Brezillon et al., J Biol Chem 2003*

Text-mined interactions from Literome

Tanaka et al., Proc Natl Acad Sci U S A 2003 : Synthetic human NPW binds and activates human GPR7 or GPR8 with EC ( 50 ) values of 0.56 nM and 0.51 nM, respectively
Guerrero et al., Bioorg Med Chem Lett 2013 : Amongst them, 5-chloro-2- ( 9H-fluoren-9-yl ) -4- ( 4-methoxyphenoxy ) pyridazin-3 ( 2H ) -one 9h ( CYM50769 ) inhibited NPW activation of NPBWR1 with a submicromolar IC ( 50 ), and displayed high selectivity against a broad array of off-targets with pharmaceutical relevance