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AKT3 — MST1
Text-mined interactions from Literome
Danilkovitch et al., J Leukoc Biol 1999
:
In addition to previously identified involvement of phosphatidylinositol 3-kinase (PI3-K), JNK, and MAPK, we found that FAK, c-Src, and
AKT are rapidly and transiently
activated by
MSP
Lutz et al., J Leukoc Biol 2003
:
MSP stimulation of macrophages
results in tyrosine phosphorylation and
AKT activation, and inhibitor studies demonstrate a phagocytic requirement for tyrosine kinase and phosphatidylinositol 3-kinase (PI-3K) activity as well as activity of the atypical protein kinase C ( PKC ) isoform zeta, which localizes to MSP induced phagosomes containing complement coated beads
Wang et al., Cancer Biol Ther 2007
(Colorectal Neoplasms) :
Introduction of RONdelta170 into HCT116 cells blocked
MSP induced Erkl/2 and
AKT phosphorylation, reduced cytoplasmic beta-catenin accumulation, restored glycogen synthase kinase-beta activity, and attenuated various tumorigenic activities
Thomas et al., Cancer Res 2007
(Disease Progression...) :
Finally,
HGFL stimulation of pancreatic cancer cells
resulted in increased expression of phospho-mitogen activated protein kinase and
phospho-Akt
Ma et al., Int J Oncol 2010
(Neoplasms) :
In colon and pancreatic cancer cells, RONDelta85 inhibits spontaneous or
MSP induced Erk1/2 and
AKT phosphorylation, which results in impaired cell proliferation and colony formation
Lebeer et al., Microbial cell factories 2012
:
In addition, the glycan chain appeared not to be required for the
activation of
Akt signaling in intestinal epithelial cells by
Msp1