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AKT3 — XIAP

Text-mined interactions from Literome

Asselin et al., Cancer Res 2001 (Ovarian Neoplasms) : XIAP regulates Akt activity and caspase-3 dependent cleavage during cisplatin induced apoptosis in human ovarian epithelial cancer cells ... Adenoviral sense XIAP cDNA expression increased XIAP protein levels and increased Akt phosphorylation, indicative of activation of Akt and, likely, of PI 3-K
Jücker et al., Leukemia 2002 (Hodgkin Disease) : A PI3-kinase dependent constitutive activation of Akt was detected in CO cells which was only partially reduced after serum starvation
Shenoy et al., J Immunol 2003 : The time courses for phosphorylation and translocation of the p85 subunit of class I ( A ) PI3K , activation of Akt , and activation of PKCzeta were similar
Fraser et al., Cancer Res 2003 (Ovarian Neoplasms) : Here we show that both Xiap and Akt can modulate CDDP sensitivity individually but that Xiap requires Akt for its full function
Gao et al., Oncogene 2005 : In these cells, enforced activation of Akt by a constitutively active myristolated Akt construct prevented 2ME mediated mitochondrial injury, XIAP and Mcl-1 downregulation, JNK activation, and apoptosis, but not ROS generation
Van Themsche et al., J Biol Chem 2007 (Endometrial Neoplasms...) : In addition, using RNA interference and pharmacological inhibitors, we show that TGF-beta increases cellular invasiveness via two distinct signaling pathways in endometrial carcinoma cells : phosphatidylinositol 3-kinase/AKT dependent up-regulation of XIAP and protein kinase C-dependent induction of matrix-metalloproteinase-9 (MMP-9) expression
Shrader et al., Cancer Res 2007 (Urinary Bladder Neoplasms) : Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT mediated X-linked inhibitor of apoptosis protein expression
Wang et al., Hematol Oncol 2008 : The levels of phosphorylated Akt ( Ser473 ) were elevated in U937/FN cells and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed XIAP expression and restored the chemosensitivity to daunorubicin
Longo et al., Blood 2008 (Leukemia, Lymphocytic, Chronic, B-Cell...) : Sustained activation of Akt resulted in increased leukemic cell viability and increased expression of the antiapoptotic proteins Mcl-1, Bcl-xL, and X-linked inhibitor of apoptosis protein ( XIAP ), thus largely recapitulating the effects of sustained BCR stimulation
Jeong et al., Neurochem Res 2009 (Brain Neoplasms...) : The expression of anti-apoptotic proteins XIAP and survivin was down-regulated by kaempferol and its effect was prevented by overexpression of MEK and Akt
Wang et al., Cancer Lett 2010 (Ovarian Neoplasms) : Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2, Bcl-xL and XIAP ), as well as activation of Ras/MEK/ERK and PI3K/Akt signaling
Déry et al., Biol Reprod 2011 (Carcinoma...) : Oxytocin increases invasive properties of endometrial cancer cells through phosphatidylinositol 3-kinase/AKT dependent up-regulation of cyclooxygenase-1, -2, and X-linked inhibitor of apoptosis protein
Hatton et al., J Biol Chem 2011 (Epstein-Barr Virus Infections...) : Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2 dependent loss of X-linked inhibitor of apoptosis protein ( XIAP ) to promote survival of Epstein-Barr virus+ ( EBV+ ) B cell lymphomas
Jiang et al., World J Gastroenterol 2012 (Pancreatic Neoplasms) : Downregulation of XIAP by transfection with XIAP shRNA resulted in decreased p-Akt expression
Pramanik et al., Carcinogenesis 2013 (Melanoma...) : Because AKT regulates XIAP , their interaction was examined by immunoprecipitation studies ... Our results revealed that AKT overexpression attenuated the decrease in XIAP and significantly blocked CAPE mediated apoptosis